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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2026; 18(1): 111871
Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.111871
Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.111871
Impact of clinically significant portal hypertension on posthepatectomy liver failure: A systematic review and meta-analysis
Ming-Hao Ruan, Fei-Yang Ye, Jin Qian, Ming-Hao Zou, Wen-Xuan Zhou, Jie Sheng, Xin-Gang Guo, Dong Wei, Hui Liu, Fu-Chen Liu, The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
Jin-Ni Ma, First School of Clinical Medicine, Anhui Medical University, Hefei 230032, Anhui Province, China
Cheng-Jing Zhang, Department of Nutrition, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
Co-first authors: Ming-Hao Ruan and Fei-Yang Ye.
Co-corresponding authors: Hui Liu and Fu-Chen Liu.
Author contributions: Ruan MH and Ye FY made equal contributions as co-first authors; Ruan MH, Ye FY, Ma JN, Qian J, Zou MH, Zhou WX, Sheng J, Guo XG, and Wei D contributed to the acquisition, analysis, and interpretation of data for this article; Ruan MH drafted the manuscript; Liu FC contributed to the manuscript revision; Zhang CJ, Liu H, and Liu FC conceived and supervised the project; Liu H and Liu FC made equal contributions as co-corresponding authors; all authors approved the final version to publish.
Supported by National Natural Science Foundation of China. No. 82302906 and No. 82270634; and 2024 Research Plan Project of the Jiading District Natural Science Foundation, No. 2024-KY-JB-30.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fu-Chen Liu, The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, No. 225 Changhai Road, Yangpu District, Shanghai 200438, China. liufuchenlfc@163.com
Received: July 14, 2025
Revised: August 21, 2025
Accepted: November 26, 2025
Published online: January 27, 2026
Processing time: 200 Days and 17.2 Hours
Revised: August 21, 2025
Accepted: November 26, 2025
Published online: January 27, 2026
Processing time: 200 Days and 17.2 Hours
Core Tip
Core Tip: The health challenges of partial hepatectomy in patients with clinically significant portal hypertension (CSPH) have been a subject of study for decades. There was no meta-analysis has systematically examined the relationship between CSPH and posthepatectomy liver failure (PHLF), despite its potential role as a critical factor in surgical decision-making. This systematic review and meta-analysis assessed PHLF in patients with and without CSPH and showed the presence of CSPH should be considered as a significant risk factor and should be taken into account seriously prior to surgery and needs strict perioperative management. Meanwhile, different methods of diagnosing CSPH could influence PHLF.