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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2025; 17(12): 111198
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.111198
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.111198
Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health
Sangam Rajak, Department of System Toxicology, FEST Division, CSIR-Indian Institute of Toxicology Research, Lucknow 226001, Uttar Pradesh, India
Ambuj Shahi, Abhishek Yadav, Pratik Medhe, Rohit A Sinha, Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Author contributions: Rajak S, Shahi A, Yadav A, Medhe P and Sinha RA wrote the paper; Sinha RA and Rajak S reviewed the literature, designed the outline and coordinated the writing of the paper; and all authors have read and agreed to the published version of the manuscript.
Supported by the Science and Engineering Research Board, No. CRG/2022/002149; and Indian Council of Medical Research, No. ICMR/02/833/IGP-2024.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rohit A Sinha, Associate Professor, Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow 226014, Uttar Pradesh, India. anthony.rohit@gmail.com
Received: June 25, 2025
Revised: July 20, 2025
Accepted: November 13, 2025
Published online: December 27, 2025
Processing time: 184 Days and 19.1 Hours
Revised: July 20, 2025
Accepted: November 13, 2025
Published online: December 27, 2025
Processing time: 184 Days and 19.1 Hours
Core Tip
Core Tip: Metabolic dysfunction-associated steatotic liver disease (MASLD), is a leading cause of severe liver disease worldwide. Intriguingly, the rise in the incidence of metabolic diseases including MASLD parallels rapid industrialization and environmental pollution worldwide. Microplastics (MPs) are a big global issue and have been found in human blood, lungs, kidneys, and liver. While some effects of MPs on liver health are known, more research is needed to understand how MPs harm the liver and how they relate to lifestyle risks. This article looks at how MPs affect liver metabolism and their role in the progression of MASLD.