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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2025; 17(12): 111153
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.111153
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.111153
Histone lactylation: A key epigenetic modulator in the pathogenesis of metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis
Mable Misha Singh, Arunim Shah, Chandra Prakash Chaturvedi, Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Sangam Rajak, FEST Division, CSIR-Indian Institute of Toxicology Research, Lucknow 226001, Uttar Pradesh, India
Rohit A Sinha, Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Author contributions: Singh MM, Shah A, Rajak S, Chaturvedi CP, and Sinha RA wrote the paper; Singh MM and Sinha RA reviewed the literature, designed the outline, and coordinated the writing of the paper; All authors have read and agreed to the published version of the manuscript.
Supported by the Science and Engineering Research Board, No. CRG/2022/002149; and the Indian Council of Medical Research, No. ICMR/02/833/IGP-2024 and No. R.12016/12/2023-HR.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rohit A Sinha, Associate Professor, Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow 226014, Uttar Pradesh, India. anthony.rohit@gmail.com
Received: June 24, 2025
Revised: August 6, 2025
Accepted: November 6, 2025
Published online: December 27, 2025
Processing time: 185 Days and 18.4 Hours
Revised: August 6, 2025
Accepted: November 6, 2025
Published online: December 27, 2025
Processing time: 185 Days and 18.4 Hours
Core Tip
Core Tip: This review article describes a biological process called histone lactylation and its role in liver diseases. Histone lactylation is a metabolically aligned epigenetic modification on histones, which can regulate hepatic gene expression. Increased lactate levels in metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis may induce histone lactylation of key genes involved in hepatic lipogenesis, inflammation and fibrosis. Consequently, pharmacological modu