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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2025; 17(12): 110993
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.110993
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.110993
Stereotactic body radiation therapy in patients with unresectable hepatocellular carcinoma and portal vein tumor thrombosis
Divya Khosla, Venkata Krishna Vamsi Gade, Rakesh Kapoor, Gaganpreet Singh, Ranjit Singh, Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Sunil Taneja, Madhumita Premkumar, Arka De, Nipun Verma, Ajay Duseja, Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Naveen Kalra, Harish Bhujade, Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Rajesh Gupta, Department of Gastrointestinal Surgery, Hepatopancreatobiliary, and Liver Transplantation, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
Co-first authors: Divya Khosla and Venkata Krishna Vamsi Gade.
Co-corresponding authors: Divya Khosla and Rakesh Kapoor.
Author contributions: Khosla D and Kapoor R contributed equally to the study and are co-corresponding authors. Khosla D and Gade VKV contributed equally to this manuscript and are co-first authors. Khosla D, Gade VKV, Kapoor R, Taneja S, Premkumar M, De A, Verma N, Duseja A, Kalra N, and Bhujade H contributed to follow-up of the patients; Khosla D and Gade VKV contributed to manuscript preparation statistical analysis; Khosla D, Kapoor R, and Gupta R contributed editing; Khosla D, Kapoor R, Singh G, and Singh R contributed to treatment; Khosla D contributed to conceptualization, study concepts and design, experimental studies, data analysis, and was guarantor of integrity of the study; Kapoor R contributed to supervision; Singh G and Singh R contributed to radiation planning and quality assurance; Gupta R, Taneja S, Premkumar M, De A, Verma N, Duseja A contributed to patient selection; Taneja S, Premkumar M, De A, Verma N, Duseja A contributed to medical management; Kalra N and Bhujade H performed radiology for diagnosis. All the authors have reviewed the manuscript for its content and approved the final version before submission.
Institutional review board statement: This study was approved by the Institutional Ethics Committee (No. IEC-INT/2025/Study-2980). On behalf of all co-authors, I confirm that the study was conducted in accordance with ethical principles and that patient confidentiality has been strictly upheld.
Informed consent statement: Our study is a retrospective analysis of de-identified patient data collected from existing medical records. No personally identifiable information has been disclosed or published at any stage of the study. In accordance with our institutional guidelines and ethical standards, the requirement for written informed consent was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data supporting the study will be available upon request after institutional approvals.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Divya Khosla, MD, Additional Professor, Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Room No. 54, Radiotherapy and Oncology Office, Ground Floor, Nehru Hospital Extension, Chandigarh 160012, India. dr_divya_khosla@yahoo.com
Received: June 23, 2025
Revised: July 22, 2025
Accepted: November 11, 2025
Published online: December 27, 2025
Processing time: 189 Days and 3.6 Hours
Revised: July 22, 2025
Accepted: November 11, 2025
Published online: December 27, 2025
Processing time: 189 Days and 3.6 Hours
Core Tip
Core Tip: Portal vein tumor thrombosis is a common and challenging presentation in hepatocellular carcinoma, significantly limiting treatment options. This retrospective study highlights the safety and efficacy of stereotactic body radiation therapy as a locoregional treatment in patients with unresectable hepatocellular carcinoma and portal vein tumor thrombosis. With an encouraging response rate of 83.3% and a median overall survival of 13 months, stereotactic body radiation therapy de