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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2025; 17(12): 110312
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.110312
Published online Dec 27, 2025. doi: 10.4254/wjh.v17.i12.110312
Impact of age on autoimmune hepatitis: A comparative study of patients diagnosed before and after sixty
Javier Delgado, Marcelo Fuentes, Daniela Simian, Jaime Poniachik, Álvaro Urzúa, Division of Gastroenterology, Department of Medicine, Hospital Clínico Universidad de Chile, Santiago 8380456, Región Metropolitana, Chile
Author contributions: Delgado J wrote the manuscript draft; Delgado J and Fuentes M collected the data; Delgado J, Simian D, and Urzúa A designed the study; Simian D performed the data analysis; Delgado J, Fuentes M, Simian D, Poniachik J, and Urzúa A reviewed and edited the final version of the manuscript.
Institutional review board statement: The study was approved by the local Ethics Committee of Hospital Clínico Universidad de Chile (N° 52/2023).
Informed consent statement: The study was approved by the local Ethics Committee of Hospital Clínico Universidad de Chile (N° 52/2023), which waived informed consent due to the retrospective nature of the research. Data confidentiality and security were ensured during data collection and analysis, with anonymized data used for statistical evaluations.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Álvaro Urzúa, MD, Division of Gastroenterology, Department of Medicine, Hospital Clínico Universidad de Chile, Dr. Carlos Lorca Tobar 999, Independencia, Santiago 8380456, Región Metropolitana, Chile. aurzuam@hcuch.cl
Received: June 12, 2025
Revised: July 1, 2025
Accepted: November 17, 2025
Published online: December 27, 2025
Processing time: 197 Days and 20.5 Hours
Revised: July 1, 2025
Accepted: November 17, 2025
Published online: December 27, 2025
Processing time: 197 Days and 20.5 Hours
Core Tip
Core Tip: This study highlights age-related differences in autoimmune hepatitis (AIH) presentation. Patients diagnosed after 60 years of age showed milder biochemical abnormalities but more advanced fibrosis and ascites at diagnosis. Despite receiving lower corticosteroid doses, their treatment response was comparable to younger patients. These findings suggest that AIH in older adults may represent a distinct clinical phenotype with important diagnostic and therapeutic implications.