Impact of alcohol-associated and metabolic dysfunction-associated steatotic liver diseases upon hepatic disorder and carcinogenesis in the current era

Core Tip

Core Tip: Alcohol and metabolic dysfunction cause steatotic changes in the hepatic parenchyma, and metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-associated liver diseases (ALD) are currently recognized as main steatotic liver disease. The ALD and MASLD result in chronic liver disease, liver fibrosis and subsequent cirrhosis. Patients accompanied with ALD and/or MASLD are currently increasing worldwide, and therefore, this editorial focuses an impact of ALD and MASLD upon hepatic disorder and carcinogenesis. From the viewpoint of carcinogenesis (i.e., hepatocellular carcinoma), chronic viral hepatitis is gradually outweighed by ALD and MASLD. Also, this editorial article mentions differences in gender and geographical region, and touches upon clinical implication for these important liver diseases.