Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma
Jun-Ling Yang, Jie Yang, Rong-Fei Fang, Wen-Li Sai, Deng-Fu Yao, Min Yao
Jun-Ling Yang, Wen-Li Sai, Deng-Fu Yao, Min Yao, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University and Department of Immunology, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China
Jie Yang, Department of Biology, Life Science School of Nantong University, Nantong 226009, Jiangsu Province, China
Rong-Fei Fang, Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Co-first authors: Jun-Ling Yang and Jie Yang.
Co-corresponding authors: Deng-Fu Yao and Min Yao.
Author contributions: Yang JL and Yang J contributed equally to this study, they are co-first authors of this manuscript. Yang JL and Yang J conceived the study and analyzed and interpreted the data; Yang J, Fang RF, and Yao M performed the experiments; Sai WL and Yao DF performed the statistical and bioinformatics analyses; Yang J, Fang RF, and Yao M acquired the materials and data; Yao DF and Yao M acquired the funding and wrote the manuscript, they contributed equally to this study and are the co-corresponding authors of this manuscript. All the authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 32470985 and No. 81673241.
Institutional review board statement: Patient recruitment was approved by the Ethics Committee of the Affiliated Hospital of Nantong University (No. 2018-L015).
Institutional animal care and use committee statement: The study involving the rat model was approved by the guidelines of the Animal Care and Use Committee of Nantong University (No. 20190304-001).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Deng-Fu Yao, MD, PhD, Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China.
yaodf@ahnmc.com
Received: June 27, 2024
Revised: August 22, 2024
Accepted: September 13, 2024
Published online: December 27, 2024
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