Synovial mesenchymal stem cell-derived exosomes delivering GRPEL1 activate PINK1-mediated mitophagy to promote cartilage repair in arthritis

doi:10.4252/wjsc.v17.i10.109369

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Oct 26, 2025 (publication date) through Oct 27, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Oct 26, 2025; 17(10): 109369
Published online Oct 26, 2025. doi: 10.4252/wjsc.v17.i10.109369

Table 1 The primer sequences used in this study

Gene		Primer sequences
GRPEL1	F	5’-AAGTTGAACCCTGTCGGAGC-3’
GRPEL1	R	5’-TGCAGCTTGTACCCCACTTT-3’
EFEMP1	F	5’-TGTGCTGTGCAAGGAACTCT-3’
EFEMP1	R	5’-CAGTGCATTGCGTGTACGTG-3’
SERPINA5	F	5’-TGTGGCAAAGCAAACGAAGG-3’
SERPINA5	R	5’-TCTTGGGTGCCTTTGTGGTT-3’
BNIP3 L	F	5’-TGCAGTTGTTTCTGCTCCCA-3’
BNIP3 L	R	5’-TAGCTCCACCCAGGAACCTT-3’

GRPEL1: GrpE-like 1; EFEMP1: Epidermal growth factor-containing fibulin extracellular matrix protein 1; SERPINA5: Serine protease inhibitor 5; BNIP3 L: Bcl2 interacting protein 3 like.

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Citation: Xiang CH, Zou L, Huang ZG, Zhang GJ, Zeng HL, He ZX, Dai ZS. Synovial mesenchymal stem cell-derived exosomes delivering GRPEL1 activate PINK1-mediated mitophagy to promote cartilage repair in arthritis. World J Stem Cells 2025; 17(10): 109369
URL: https://www.wjgnet.com/1948-0210/full/v17/i10/109369.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i10.109369