Advancing mechanistic insights and clinical translation of exosomal miR-137-3p in endometrial regeneration

Figure 1 Advancing mechanistic insights and clinical translation of exosomal miR-137-3p in endometrial regeneration. Elucidating the mechanisms underlying microRNA regulatory networks, multiple signaling pathways, and signal transducer and activator of transcription 3-hypoxia-inducible factor-1α crosstalk will further enhance our understanding of the functional roles of exosomal miR-137-3p. Additionally, optimizing exosome delivery protocols, safety profiles, and tissue-targeting strategies will be instrumental in promoting the clinical translation of endometrial regeneration therapies. miRNAs: MicroRNAs; UBE3C: Ubiquitin protein ligase E3C; Wnt: Wingless; AKT: Protein kinase B; mTOR: Mechanistic target of rapamycin; STAT3: Signal transducer and activator of transcription 3; HIF-1α: Hypoxia-inducible factor-1α; MAPK: Mitogen-activated protein kinase; HucMSC: Human umbilical cord mesenchymal stem cell.