Han LF, Fu GK, Wen YQ, Bian XL. Advancing mechanistic insights and clinical translation of exosomal miR-137-3p in endometrial regeneration. World J Stem Cells 2025; 17(8): 109106 [DOI: 10.4252/wjsc.v17.i8.109106]
Corresponding Author of This Article
Xue-Li Bian, PhD, Professor, School of Basic Medical Science, Nanchang University, No. 1299 Xuefu Road, Honggutan District, Nanchang 330031, Jiangxi Province, China. bianxueli@ncu.edu.cn
Research Domain of This Article
Biology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Aug 26, 2025; 17(8): 109106 Published online Aug 26, 2025. doi: 10.4252/wjsc.v17.i8.109106
Advancing mechanistic insights and clinical translation of exosomal miR-137-3p in endometrial regeneration
Lin-Fen Han, Guo-Kai Fu, Yue-Qi Wen, Xue-Li Bian
Lin-Fen Han, Guo-Kai Fu, Yue-Qi Wen, Xue-Li Bian, School of Basic Medical Science, Nanchang University, Nanchang 330031, Jiangxi Province, China
Author contributions: Han LF, Fu GK, and Wen YQ participated in drafting the manuscript; Han LF and Bian XL wrote the original draft; Bian XL supervised the project, finalized the draft, and made substantial revisions to the manuscript. All authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Li Bian, PhD, Professor, School of Basic Medical Science, Nanchang University, No. 1299 Xuefu Road, Honggutan District, Nanchang 330031, Jiangxi Province, China. bianxueli@ncu.edu.cn
Received: April 30, 2025 Revised: June 10, 2025 Accepted: July 14, 2025 Published online: August 26, 2025 Processing time: 114 Days and 4.8 Hours
Abstract
This study by Zhang et al elucidates the role of exosome miR-137-3p targeting ubiquitin protein ligase E3C to activate signal transducer and activator of transcription 3 under hypoxia conditions, thereby promoting the migration and differentiation of human umbilical cord mesenchymal stem cells to endometrial epithelial cells. It emphasizes that exosomal miR-137-3p/ubiquitin protein ligase E3C/signal transducer and activator of transcription 3 axis is a promising pathway for endometrial regeneration. This article introduced the therapeutic potential of exosomal microRNAs in regenerative medicine while underscoring the need for standardized protocols in optimizing exosome delivery and validating molecular pathways for clinical translation.
Core Tip: Zhang et al employed integrated bioinformatics analysis and functional validation to demonstrate that hypoxia-induced exosomal miR-137-3p promotes human umbilical cord mesenchymal stem cell migration and differentiation into endometrial epithelial cells by targeting ubiquitin protein ligase E3C and activating the signal transducer and activator of transcription 3. These findings provide novel insights into exosome-mediated stem cell therapy for thin endometrium. This article underscored the paramount importance of elucidating underlying mechanisms and rigorously assessing translational potential. Further investigation focusing on mechanism depth and transformation feasibility is essential to robustly facilitate the clinical translation of this promising therapeutic strategy.
