©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2015; 7(7): 992-998
Published online Aug 26, 2015. doi: 10.4252/wjsc.v7.i7.992
Published online Aug 26, 2015. doi: 10.4252/wjsc.v7.i7.992
Signaling involved in stem cell reprogramming and differentiation
Shihori Tanabe, National Institute of Health Sciences, Tokyo 158-8501, Japan
Author contributions: Tanabe S is the sole contributor to this paper.
Conflict-of-interest statement: The author declares that no conflict of interest exists.
Correspondence to: Shihori Tanabe, PhD, Senior Researcher at the National Institute of Health Sciences, 1-18-1, Kami-yoga, Setagaya-ku, Tokyo 158-8501, Japan. stanabe@nihs.go.jp
Telephone: +81-3-37001141 Fax: +81-3-37076950
Received: April 21, 2015
Peer-review started: April 24, 2015
First decision: May 13, 2015
Revised: May 29, 2015
Accepted: June 18, 2015
Article in press: June 19, 2015
Published online: August 26, 2015
Processing time: 127 Days and 18.9 Hours
Peer-review started: April 24, 2015
First decision: May 13, 2015
Revised: May 29, 2015
Accepted: June 18, 2015
Article in press: June 19, 2015
Published online: August 26, 2015
Processing time: 127 Days and 18.9 Hours
Core Tip
Core tip: Signals in stem cell are regulated both genetically and epigenetically by many molecules. The programming of stem cell signaling is an important aspect of understanding stem cell phenotype transitions and functions. The differentiation process as well as intra- and inter-cellular signaling of stem cells is described in this article. The epigenetic regulation of these cells is also discussed.