Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Mar 26, 2015; 7(2): 253-265
Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.253
Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment
Ying Xiong, Lindsay T McDonald, Dayvia L Russell, Ryan R Kelly, Katie R Wilson, Meenal Mehrotra, Adam C Soloff, Amanda C LaRue
Ying Xiong, Lindsay T McDonald, Dayvia L Russell, Ryan R Kelly, Katie R Wilson, Meenal Mehrotra, Adam C Soloff, Amanda C LaRue, Research Services, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC 29403, United States
Ying Xiong, Lindsay T McDonald, Dayvia L Russell, Ryan R Kelly, Katie R Wilson, Meenal Mehrotra, Amanda C LaRue, Department of Pathology and Laboratory Medicine, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC 29403, United States
Ying Xiong, Lindsay T McDonald, Meenal Mehrotra, Adam C Soloff, Amanda C LaRue, the Hollings Cancer Center, Medical University of South Carolina, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC 29403, United States
Adam C Soloff, Department of Microbiology and Immunology, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC 29403, United States
Author contributions: Xiong Y and McDonald LT contributed equally to this work; all authors contributed to the concept, drafting, revising and final editing of this manuscript.
Supported by In part by the NIH/NCI (R01 CA148772, ACL); by the Biomedical Laboratory Research and Development Program of the Department of Veterans Affairs (Merit Awards, ACL); and by the Hollings Cancer Center (Translational Research Pilot Project, P30 CA138313, ACL).
Conflict-of-interest: The authors have no conflict of interest related to the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Amanda C LaRue, PhD, Research Health Scientist and Associate Professor, Research Services, Ralph H Johnson Veterans Affairs Medical Center, 109 Bee Street, Charleston, SC 29403, United States. laruerc@musc.edu
Telephone: +1-843-7896713 Fax: +1-843-8765381
Received: July 29, 2014
Peer-review started: July 29, 2014
First decision: October 16, 2014
Revised: November 8, 2014
Accepted: November 27, 2014
Article in press: December 1, 2014
Published online: March 26, 2015
Processing time: 234 Days and 6.7 Hours
Core Tip

Core tip: This review examines the roles of cancer-associated adipocytes (CAAs) and cancer-associated fibroblasts (CAFs) in remodeling of the tumor microenvironment (TME), presents evidence for a unique hematopoietic stem cell origin for both CAAs and CAFs, and discusses potential therapeutic implications of this novel origin. Studies highlighted herein emphasize the necessity of developing an understanding of the origins of cells in the TME and the importance of multipronged therapeutic targets directed at preventing both the incorporation and effects of stromal remodeling by the cells of the TME.