Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Stem Cells. Apr 26, 2026; 18(4): 117067
Published online Apr 26, 2026. doi: 10.4252/wjsc.v18.i4.117067
Published online Apr 26, 2026. doi: 10.4252/wjsc.v18.i4.117067
Association of peripheral blood-derived mesenchymal stem cells exosomal circular RNAs with diagnosis and inflammatory response in acute mesenteric ischemia
Guo-Liang Wang, Jian-Qi Ni, Yi-Feng Shen, Liu Xu, Qin Jin, Department of Vascular Surgery, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing 314001, Zhejiang Province, China
Qing Li, Department of Pulmonary and Critical Care Medicine, Xianning Central Hospital, First Affiliated Hospital of Hubei University of Science and Technology, Xianning 437000, Hubei Province, China
Author contributions: Wang GL conducted the majority of experiments and wrote the manuscript; Li Q designed the study and served as a scientific advisor and guarantor; Ni JQ corrected the manuscript; Shen YF was involved in applying the analytical tools; Xu L and Jin Q participated in the collection of human material.
Supported by the Joint Development of Disciplines by Jiaxing City and Provincial Government; and the National Key Clinical Specialty Construction Project, No. 2023-GJZK-001.
Institutional review board statement: This study was approved by First Hospital of Jiaxing (Approval No. 2024-LP-159), and the study followed the ethical guidelines of the Declaration of Helsinki.
Informed consent statement: Informed consent was obtained from all study participants.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Corresponding author: Qin Jin, Chief Physician, Department of Vascular Surgery, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, No. 1882 Zhonghuan South Road, Jiaxing 314001, Zhejiang Province, China. chinekim@163.com
Received: December 5, 2025
Revised: January 4, 2026
Accepted: February 9, 2026
Published online: April 26, 2026
Processing time: 136 Days and 0.1 Hours
Revised: January 4, 2026
Accepted: February 9, 2026
Published online: April 26, 2026
Processing time: 136 Days and 0.1 Hours
Core Tip
Core Tip: Peripheral blood-derived mesenchymal stem cells exosomal circ-Eya3 and circEZH2_005 serve as novel biomarkers for acute mesenteric ischemia (AMI), reflecting intestinal injury severity, systemic inflammation, and disease subtype. Their integration with D-lactate enables high-accuracy diagnosis, whereas differential expression across arterial/venous AMI and ischemia stages offers clinical utility for guiding intervention strategies. Peripheral blood-derived mesenchymal stem cells exosomal circ-Eya3 and circEZH2_005 are promising biomarkers for the early diagnosis, subtyping, staging, and post-reperfusion monitoring of AMI.