Wang AR, Zhang YY, Liu YJ, Ren LN, Yan QH, Wang KF, Wang Y. Exosomes of adipose-derived mesenchymal stem cells loaded with globular adiponectin improve islet function for type 2 diabetes. World J Stem Cells 2026; 18(3): 115363 [DOI: 10.4252/wjsc.v18.i3.115363]
Corresponding Author of This Article
Yan Wang, Department of Endocrinology, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan 030001, Shanxi Province, China. wysdyy@126.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mar 26, 2026 (publication date) through Mar 28, 2026
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Stem Cells
ISSN
1948-0210
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Wang AR, Zhang YY, Liu YJ, Ren LN, Yan QH, Wang KF, Wang Y. Exosomes of adipose-derived mesenchymal stem cells loaded with globular adiponectin improve islet function for type 2 diabetes. World J Stem Cells 2026; 18(3): 115363 [DOI: 10.4252/wjsc.v18.i3.115363]
World J Stem Cells. Mar 26, 2026; 18(3): 115363 Published online Mar 26, 2026. doi: 10.4252/wjsc.v18.i3.115363
Exosomes of adipose-derived mesenchymal stem cells loaded with globular adiponectin improve islet function for type 2 diabetes
An-Ran Wang, Yu-Yang Zhang, Yi-Jun Liu, Li-Nan Ren, Qi-Hui Yan, Kai-Fang Wang, Yan Wang
An-Ran Wang, Department of Endocrinology, School of Medical Sciences, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Yu-Yang Zhang, Department of Endocrinology, First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Yi-Jun Liu, Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Li-Nan Ren, Qi-Hui Yan, Yan Wang, Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Kai-Fang Wang, Department of Cardiology, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Co-first authors: An-Ran Wang and Yu-Yang Zhang.
Co-corresponding authors: Kai-Fang Wang and Yan Wang.
Author contributions: Wang AR and Zhang YY contributed equally to this manuscript and are co-first authors of this manuscript. Wang AR and Zhang YY performed the experiments, acquired analyzed data and wrote the manuscript; Liu YJ, Ren LN, and Yan QH modified the article; Wang KF and Wang Y are the co-corresponding authors of this manuscript. Wang KF oversaw the design and coordination of the experimental work; Wang Y acquired the financial support for the project and oversaw the design and coordination of the experimental work; and all authors approved the final version of the article.
Supported by Basic Research Program of Shanxi Province, No. 20210302123241.
Institutional animal care and use committee statement: All the animal experimental procedures were approved by the Animal Care and Use Committee of Shanxi Medical University (approval No. SYDL2025024).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Corresponding author: Yan Wang, Department of Endocrinology, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan 030001, Shanxi Province, China. wysdyy@126.com
Received: October 17, 2025 Revised: November 23, 2025 Accepted: January 26, 2026 Published online: March 26, 2026 Processing time: 161 Days and 4.5 Hours
Core Tip
Core Tip: Researchers have developed a promising new approach to treat type 2 diabetes using exosomes (Exos) derived from adipose-derived mesenchymal stem cells loaded with globular adiponectin (gAd) - referred to as gAd-Exo. The combination of gAd and Exo produced a significant synergistic effect. In a diabetic rat model, gAd-Exo significantly lowered blood glucose, reduced pancreatic islet cell death, and improved insulin sensitivity. It also helped restore the structure and function of pancreatic islets. Mechanistically, gAd-Exo activated key metabolic pathway - AMP-activated protein kinase/acetyl-CoA carboxylase - which are crucial for energy metabolism and cell survival. This study highlights the potential of Exo-mediated delivery to enhance the efficacy of therapeutic molecules like gAd, offering a targeted and sustained treatment strategy for type 2 diabetes.
