©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
World J Stem Cells. Feb 26, 2026; 18(2): 114980
Published online Feb 26, 2026. doi: 10.4252/wjsc.v18.i2.114980
Published online Feb 26, 2026. doi: 10.4252/wjsc.v18.i2.114980
Sclerostin silencing in human umbilical cord mesenchymal stem cells enhances bone regeneration via Wnt pathway activation
Prashasti Sharma, Dharmendra Kumar Maurya, Life Sciences, Homi Bhabha National Institute, Mumbai 400094, Maharashtra, India
Prashasti Sharma, Dharmendra Kumar Maurya, Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, Maharashtra, India
Author contributions: Sharma P has done a review of the literature, and drawn the scheme; Maurya DK has written the editorial.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Dharmendra Kumar Maurya, PhD, Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, 3-82-S, A-Block, Modular Laboratory, Mumbai 400085, Maharashtra, India. dkmaurya@barc.gov.in
Received: October 11, 2025
Revised: November 10, 2025
Accepted: January 15, 2026
Published online: February 26, 2026
Processing time: 133 Days and 22.9 Hours
Revised: November 10, 2025
Accepted: January 15, 2026
Published online: February 26, 2026
Processing time: 133 Days and 22.9 Hours
Core Tip
Core Tip: Silencing sclerostin in human umbilical cord mesenchymal stem cells enhances their bone-regenerative potential by activating the Wnt/β-catenin signaling pathway, providing a novel therapeutic approach for steroid-induced avascular necrosis of the femoral head. In the study by Lv et al, sh-human umbilical cord mesenchymal stem cells demonstrated better osteogenesis, suppressed adipogenesis, and improved bone architecture in a steroid-induced rat model compared to unmo