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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jan 26, 2026; 18(1): 112278
Published online Jan 26, 2026. doi: 10.4252/wjsc.v18.i1.112278
Published online Jan 26, 2026. doi: 10.4252/wjsc.v18.i1.112278
Hypoxia facilitates triple-negative breast cancer stem cells enrichment and stemness maintenance through oxidized ataxia telangiectasia mutated-induced one-carbon metabolism
Dan Yang, Yu-Lian Ou, Shu-Hui Wang, Hong-Jun Jin, Su-Hua Chen, Hua Zhang, Clinical Laboratory, Guizhou Provincial People’s Hospital, Guiyang 550002, Guizhou Province, China
Ran Han, Outpatient Department, Guizhou Provincial People’s Hospital, Guiyang 550002, Guizhou Province, China
Co-first authors: Dan Yang and Yu-Lian Ou.
Co-corresponding authors: Ran Han and Hua Zhang.
Author contributions: Yang D and Ou YL contributed equally to this manuscript and are co-first authors. Yang D, Ou YL, Han R, and Zhang H conceived and designed the study, and wrote the original draft; Yang D, Ou YL, and Chen SH performed the experiments and data analysis; Han R and Zhang H reviewed and edited the manuscript; Wang SH and Jin HJ provided supervision and project administration; Yang D and Han R acquired funding. Han R and Zhang H contributed equally to this manuscript and are co-corresponding authors. All authors have read and approved the final manuscript.
Institutional review board statement: This study didn’t include any human issues or animals.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used to support the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ran Han, Outpatient Department, Guizhou Provincial People’s Hospital, No. 83 Zhongshan East Road, Guiyang 550002, Guizhou Province, China.
Received: July 23, 2025
Revised: September 9, 2025
Accepted: December 2, 2025
Published online: January 26, 2026
Processing time: 181 Days and 21.1 Hours
Revised: September 9, 2025
Accepted: December 2, 2025
Published online: January 26, 2026
Processing time: 181 Days and 21.1 Hours
Core Tip
Core Tip: This study demonstrates that hypoxia activates oxidized ataxia telangiectasia mutated kinase, which plays a pivotal role in enhancing the stemness of triple-negative breast cancer stem cells. Through c-Myc-mediated transcriptional regu