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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jan 26, 2026; 18(1): 110470
Published online Jan 26, 2026. doi: 10.4252/wjsc.v18.i1.110470
Published online Jan 26, 2026. doi: 10.4252/wjsc.v18.i1.110470
Adipose-derived mesenchymal stem cells from solid tissue and lipoaspirates: A comparative study of phenotype, growth, and secretome
Phuong Thi Minh Dam, Anh Thi Thu Ngo, Anh Minh Tran, Truc Thanh Nguyen, Phong Van Nguyen, Chi Quynh Nguyen, Anh Thi Tuyet Nguyen, Quynh-Trang Thi Pham, Uyen Thi Trang Than, Vinmec Hi-Tech Center, Vinmec Healthcare System, Ha Noi 100000, Vietnam
Dai Dang Nguyen, Vinmec International Hospital, Vinmec Healthcare System, Ha Noi 100000, Vietnam
Quynh-Trang Thi Pham, Uyen Thi Trang Than, Vinmec-VinUni Institute of Immunology, College of Health Sciences, VinUniversity, Ha Noi 100000, Vietnam
Author contributions: Dam PTM and Than UTT designed the experiments; Dam PTM, Nguyen DD, and Than UTT provided the study materials or patients; Ngo ATT, Tran AM, Nguyen TT, Nguyen PV, Nguyen CQ, Nguyen ATT, and Pham QTT performed the studies; Than UTT reviewed the data and manuscript content; All authors performed the studies, analyzed the data, and wrote the manuscript.
Institutional review board statement: The study was reviewed and approved by the Vinmec International General Hospital Joint Stock Company’s Ethics Committee (Ethical approval number: 01/2023/CN-HĐĐĐ VMEC). Tissues were only harvested when donors signed written informed consent before donating their samples.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Uyen Thi Trang Than, PhD, Assistant Professor, Vinmec-VinUni Institute of Immunology, College of Health Sciences, VinUniversity, Ocean Park, Da Ton, Gia Lam, Ha Noi 100000, Viet Nam. uyen.ttt@vinuni.edu.vn
Received: June 10, 2025
Revised: July 20, 2025
Accepted: November 18, 2025
Published online: January 26, 2026
Processing time: 227 Days and 12.2 Hours
Revised: July 20, 2025
Accepted: November 18, 2025
Published online: January 26, 2026
Processing time: 227 Days and 12.2 Hours
Core Tip
Core Tip: This study compared mesenchymal stem cells (MSC) derived from solid adipose tissue and lipoaspirates, showing that both sources yielded cells with similar morphology, growth, stemness, and differentiation potential. While overall characteristics were comparable, some growth factors were uniquely expressed depending on the source. These findings support the suitability of both adipose sources for MSC isolation and highlight subtle differences that may influence future therapeutic applications.