Advances in mesenchymal stem cell-based therapies for recurrent spontaneous abortion

doi:10.4252/wjsc.v17.i8.108695

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Aug 26, 2025 (publication date) through Aug 21, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Aug 26, 2025; 17(8): 108695
Published online Aug 26, 2025. doi: 10.4252/wjsc.v17.i8.108695

Advances in mesenchymal stem cell-based therapies for recurrent spontaneous abortion

Yi Xiao, Fan-Yu Zeng, Zhen-Yu Chen, Feng Zhao, Jing-Li Sun

Yi Xiao, Fan-Yu Zeng, Zhen-Yu Chen, Department of Obstetrics and Gynecology, General Hospital of Northern Theater Command, Shenyang 110000, Liaoning Province, China

Feng Zhao, Department of Basic Medical, China Medical University, Shenyang 110000, Liaoning Province, China

Jing-Li Sun, Department of Obstetrics and Gynecology, General Hospital of Northern Theater Command (Heping Campus), Shenyang 110000, Liaoning Province, China

Co-first authors: Yi Xiao and Fan-Yu Zeng.

Author contributions: Xiao Y and Zeng FY contributed equally and share first authorship. Xiao Y and Zeng FY authored the manuscript’s initial draft; Chen ZY and Zhao F contributed to review and editing; Sun JL conceived, evaluated, and revised this paper. All authors read and approved the final manuscript.

Supported by the Natural Science Foundation of Liaoning Province, No. 2024-MSLH-525.

Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jing-Li Sun, Chief Physician, Department of Obstetrics and Gynecology, General Hospital of Northern Theater Command (Heping Campus), No. 5 Guangrong Street, Heping District, Shenyang 110000, Liaoning Province, China. zg3416@sina.com

Received: April 21, 2025
Revised: May 29, 2025
Accepted: July 3, 2025
Published online: August 26, 2025
Processing time: 122 Days and 16.8 Hours

Core Tip

Core Tip: The reproductive health of women of childbearing age is significantly impacted by recurrent spontaneous abortion. Although there are several therapeutic options available today, the curative efficacy is unsatisfactory. By controlling immunological factors, mesenchymal stem cell therapy is one possible treatment option that can enhance pregnancy outcomes. Mesenchymal stem cell treatment and its associated mechanisms are briefly explained in this article.