Current perspectives on regenerative potential of mesenchymal stem cells in alleviating cardiac injuries: Molecular pathways and therapeutic enhancement

doi:10.4252/wjsc.v17.i8.107480

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Aug 26, 2025 (publication date) through Aug 21, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Aug 26, 2025; 17(8): 107480
Published online Aug 26, 2025. doi: 10.4252/wjsc.v17.i8.107480

Current perspectives on regenerative potential of mesenchymal stem cells in alleviating cardiac injuries: Molecular pathways and therapeutic enhancement

Asmaa M ShamsEldeen, Sara A Hosny, Khaled Maghib, Hend Ashour

Asmaa M ShamsEldeen, Department of Physiology, Cairo University, Cairo 11956, Egypt

Sara A Hosny, Department of Histology and Cell Biology, Faculty of Medicine, Cairo University, Cairo 11956, Egypt

Khaled Maghib, Faculty of Medicine, Cairo University, Cairo 11956, Egypt

Hend Ashour, Department of Physiology, Faculty of Medicine, King Khalid University, Abha 61421, Saudi Arabia

Hend Ashour, Department of Physiology, Faculty of Medicine, Cairo University, Cairo 11956, Egypt

Author contributions: ShamsEldeen AM and Ashour H conceptualized the main points, drafted the original manuscript, and revised the text; Hosny SA and Maghib K drafted the original manuscript and revised the text. All authors reviewed and approved the final manuscript.

Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Asmaa M ShamsEldeen, MD, Assistant Professor, Department of Physiology, Cairo University, Al-Saray Street, Cairo 11956, Egypt. asmaa82shamseldeen@gmail.com

Received: March 25, 2025
Revised: April 12, 2025
Accepted: July 10, 2025
Published online: August 26, 2025
Processing time: 149 Days and 22.2 Hours

Core Tip

Core Tip: In clinical and experimental research, mesenchymal stem cells (MSCs) are thought to hold promising therapeutic potential. Globally, cardiovascular diseases remain the leading cause of mortality. Thus, studying the specific molecular pathways by which MSCs mitigate cardiac injuries is essential to improving their therapeutic applications in the future. Through their immunoregulatory, anti-apoptotic, antifibrotic, antioxidant, and angiogenic activities, MSCs can influence the course of cardiovascular diseases. Successful homing and engraftment are necessary for the regenerative capacity of MSCs. Meanwhile, this review also focuses on the underlying mechanisms of MSC homing and the challenges that may hinder their effects.