Zhang B, Gao BD, Su Y, Mi WJ, Zeng TX, Ma FF, Ha XQ. Human umbilical cord mesenchymal stem cells reduce platelet α-granule release in rats via the AKT/MEK/ERK pathway during acute exposure to high-altitude hypoxia. World J Stem Cells 2025; 17(6): 106272 [PMID: 40585956 DOI: 10.4252/wjsc.v17.i6.106272]
Corresponding Author of This Article
Xiao-Qin Ha, Clinical Laboratory, The 940th Hospital of the PLA Joint Logistics Support Force, No. 333 Nanbinhe Road, Qilihe District, Lanzhou 730000, Gansu Province, China. haxiaoqin2013@163.com
Research Domain of This Article
Hematology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jun 26, 2025 (publication date) through Feb 28, 2026
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Stem Cells
ISSN
1948-0210
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Zhang B, Gao BD, Su Y, Mi WJ, Zeng TX, Ma FF, Ha XQ. Human umbilical cord mesenchymal stem cells reduce platelet α-granule release in rats via the AKT/MEK/ERK pathway during acute exposure to high-altitude hypoxia. World J Stem Cells 2025; 17(6): 106272 [PMID: 40585956 DOI: 10.4252/wjsc.v17.i6.106272]
World J Stem Cells. Jun 26, 2025; 17(6): 106272 Published online Jun 26, 2025. doi: 10.4252/wjsc.v17.i6.106272
Human umbilical cord mesenchymal stem cells reduce platelet α-granule release in rats via the AKT/MEK/ERK pathway during acute exposure to high-altitude hypoxia
Bo Zhang, Bao-Dong Gao, Yuan Su, Wen-Jing Mi, Tong-Xu Zeng, Fei-Fei Ma, Xiao-Qin Ha
Bo Zhang, Bao-Dong Gao, Yuan Su, Wen-Jing Mi, Tong-Xu Zeng, Fei-Fei Ma, Xiao-Qin Ha, Clinical Laboratory, The 940th Hospital of the PLA Joint Logistics Support Force, Lanzhou 730000, Gansu Province, China
Bo Zhang, Bao-Dong Gao, Yuan Su, Wen-Jing Mi, Tong-Xu Zeng, Fei-Fei Ma, Xiao-Qin Ha, Key Laboratory of Stem Cell and Gene Medicine, Lanzhou 730000, Gansu Province, China
Co-first authors: Bo Zhang and Bao-Dong Gao.
Author contributions: Zhang B and Gao BD performed the experiments, they contributed equally to this article as co-first authors; Zhang B and Ha XQ made substantial contributions to the conception and design of the study, drafting the article and critically revising it for important intellectual content; Zhang B, Su Y, Mi WJ, Zeng TX, and Ma FF acquired and analyzed the data; Ha XQ contributed to the discussion of the data, funding acquisition and supervision. All authors approved the final version for publication.
Supported by the Major Science and Technology Project of Gansu Province - Social Development Field, No. 25ZDFA007; Health Industry Research Funding Project of Gansu Province, No. GSWSKY2024-54; Youth Science and Technology Fund Program of Gansu Province, No. 21JR11RA014; National Natural Science Foundation of China, No. 81273568; Health Industry Research Funding Project of Gansu Province, No. GSWSKY2022-03; and Logistics Scientific Research Independent Project of the PLA.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the 940th Hospital of the PLA Joint Logistics Support Force (approval No. 2024KYLL314D).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the 940th Hospital of the PLA Joint Logistics Support Force (Protocol No. 2024KYLL312D).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Corresponding author: Xiao-Qin Ha, Clinical Laboratory, The 940th Hospital of the PLA Joint Logistics Support Force, No. 333 Nanbinhe Road, Qilihe District, Lanzhou 730000, Gansu Province, China. haxiaoqin2013@163.com
Received: February 21, 2025 Revised: April 2, 2025 Accepted: June 12, 2025 Published online: June 26, 2025 Processing time: 125 Days and 2.1 Hours
Core Tip
Core Tip: The effects of human umbilical cord mesenchymal stem cell (hUC-MSC) on platelet α-granules in rats during acute exposure to high-altitude hypoxia were assessed. hUC-MSCs significantly reduced platelet counts and plasma levels of von Willebrand factor, platelet factor 4, and beta-thromboglobulin, as well as the expression of CD62p on platelet surfaces. Additionally, hUC-MSCs improved platelet morphology and reduced pseudopodia formation and α-granule contents. These effects were mediated by activation of the protein kinase B/mitogen-activated protein kinase/extracellular-signal regulated kinase signaling pathway. The findings suggest that hUC-MSCs may represent a promising preventive strategy against acute high-altitude-associated thrombosis, and provide empirical support for their expanded clinical application.
