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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2025; 17(12): 113924
Published online Dec 26, 2025. doi: 10.4252/wjsc.v17.i12.113924
Published online Dec 26, 2025. doi: 10.4252/wjsc.v17.i12.113924
Exercise with induced pluripotent stem cells enhances Wnt1-Lmx1a signaling and dopaminergic neurogenesis to alleviate Parkinsonian symptoms
Aya Arafat, Clinical and Chemical Pathology Department, Faculty of Medicine Cairo University, Cairo 11562, Al Qāhirah, Egypt
Soliman Mehawed Abdellatif Soliman, Thoraya A Farghaly, Department of Chemistry, Faculty of Science, Cairo University, Cairo 12613, Al Qāhirah, Egypt
Thoraya A Farghaly, Department of Chemistry, Umm Al-Qura University, Makkah 21955, Saudi Arabia
Noura A A Ebrahim, Department of Oncologic Pathology, National Cancer Institute, Cairo University, Cairo 11796, Al Qāhirah, Egypt
Co-first authors: Aya Arafat and Soliman Mehawed Abdellatif Soliman.
Co-corresponding authors: Thoraya A Farghaly and Noura A A Ebrahim.
Author contributions: Arafat A and Soliman SMA contributed equally to this manuscript and are co-first authors. Arafat A, Soliman SMA, Farghaly TA, and Ebrahim NAA contributed to the manuscript writing and revision. Farghaly TA and Ebrahim NAA contributed equally to this manuscript and are co-corresponding authors.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Noura A A Ebrahim, Department of Oncologic Pathology, National Cancer Institute, Cairo University, 1st Kasr Alainy Street, Cairo 11796, Al Qāhirah, Egypt.
Received: September 7, 2025
Revised: October 25, 2025
Accepted: December 3, 2025
Published online: December 26, 2025
Processing time: 109 Days and 14 Hours
Revised: October 25, 2025
Accepted: December 3, 2025
Published online: December 26, 2025
Processing time: 109 Days and 14 Hours
Core Tip
Core Tip: This letter builds on Jiang et al’s recent findings that voluntary exercise enhances the therapeutic impact of induced pluripotent stem cell transplantation in Parkinson’s disease by activating the Wnt1-Lmx1a pathway. We highlight exercise as a molecular modulator that fosters a neurogenic milieu, recommend examining additional developmental signals (sonic hedgehog, fibroblast growth factor 8, bone morphogenetic protein), and suggest biomaterial-based strategies to support graft survival and integration. We also stress the need to optimize exercise regimens in relation to transplantation, framing these insights within a translational strategy for advancing regenerative therapies in Parkinson’s disease.