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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Nov 26, 2025; 17(11): 113032
Published online Nov 26, 2025. doi: 10.4252/wjsc.v17.i11.113032
Published online Nov 26, 2025. doi: 10.4252/wjsc.v17.i11.113032
Mitochondrial regulation of stem cell osteogenic differentiation: A key driver for bone regeneration
Jing-Shun Lu, Yuan-Sheng Huang, Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu 241000, Anhui Province, China
Yun-Hong Zhao, Fei-Yan Mu, Southern Central Hospital of Yunnan Province, The First People’s Hospital of Honghe State, Mengzi 661100, Yunnan Province, China
Chen-Yu Song, Kai-Yang Wang, Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
Min Yang, Department of Traditional Chinese Medicine, Meilong Community Health Service Center of Minhang District, Shanghai 200233, China
Author contributions: Lu JS wrote and edited the manuscript; Song CY, Yang M, and Huang YS contributed to review and edit; Zhao YH and Mu FY reviewed this paper; Wang KY conceived, reviewed, and revised this paper.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kai-Yang Wang, MD, Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, China. ortho_wang@163.com
Received: August 13, 2025
Revised: September 21, 2025
Accepted: November 12, 2025
Published online: November 26, 2025
Processing time: 105 Days and 7.7 Hours
Revised: September 21, 2025
Accepted: November 12, 2025
Published online: November 26, 2025
Processing time: 105 Days and 7.7 Hours
Core Tip
Core Tip: Mesenchymal stem cells (MSCs) hold promise for bone regeneration, but their potential is limited by poor osteogenic differentiation. Mitochondria play a pivotal role in bone defect repair, where their functions in energy meta