Islam MA, Mawya J, Salma U, Abu Kasim NH, Haque N. Unravelling the reversion mechanisms of activated hepatic stellate cell properties by extracellular vesicles from mesenchymal stem cells. World J Stem Cells 2025; 17(11): 111090 [DOI: 10.4252/wjsc.v17.i11.111090]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 26, 2025 (publication date) through Nov 26, 2025
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World Journal of Stem Cells
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1948-0210
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Islam MA, Mawya J, Salma U, Abu Kasim NH, Haque N. Unravelling the reversion mechanisms of activated hepatic stellate cell properties by extracellular vesicles from mesenchymal stem cells. World J Stem Cells 2025; 17(11): 111090 [DOI: 10.4252/wjsc.v17.i11.111090]
World J Stem Cells. Nov 26, 2025; 17(11): 111090 Published online Nov 26, 2025. doi: 10.4252/wjsc.v17.i11.111090
Unravelling the reversion mechanisms of activated hepatic stellate cell properties by extracellular vesicles from mesenchymal stem cells
Md Ariful Islam, Jannatul Mawya, Umme Salma, Noor Hayaty Abu Kasim, Nazmul Haque
Md Ariful Islam, Jannatul Mawya, Nazmul Haque, Department of Regenerative Medicine, Concord Stem Cell Limited, Dhaka 1209, Bangladesh
Umme Salma, Department of Regenerative Medicine, Freelance Researcher, Dhaka 1209, Bangladesh
Noor Hayaty Abu Kasim, Department of Restorative Dentistry, University of Malaya, Kuala Lumpur 50603, Malaysia
Co-corresponding authors: Noor Hayaty Abu Kasim and Nazmul Haque.
Author contributions: Islam MA and Mawya J significantly contributed to the manuscript preparing; Haque N contributed to the conception and design of the study; Islam MA, Mawya J, and Salma U drafted and wrote the article; Abu Kasim NH and Haque N contributed to the manuscript writing, made critical revisions related to relevant intellectual content of the manuscript, and approved the final version of the article. Abu Kasim NH and Haque N contributed equally to this manuscript and are co-corresponding authors.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: June 23, 2025 Revised: July 31, 2025 Accepted: October 9, 2025 Published online: November 26, 2025 Processing time: 156 Days and 16.2 Hours
Core Tip
Core Tip: Liver fibrosis and cirrhosis are global health challenges resulting from persistent liver injury, hepatocyte damage, inflammation, and hepatic stellate cell activation. These processes dysregulate key signaling pathways such as transforming growth factor beta/small mother against decapentaplegic, Wnt/β-catenin, nuclear factor-kappa B, and mitogen-activated protein kinase, leading to excessive extracellular matrix deposition. Importantly, once the underlying cause is addressed, liver’s natural ability to regenerate and regress fibrosis is restored. Innovative approaches such as mesenchymal stem cell-derived extracellular vesicles and microRNA-based therapies are gaining attention due to their potential to deliver targeted anti-fibrotic molecules, regulate gene expression, and reverse liver fibrosis. Ultimately, these strategies could lessen the burden of chronic liver diseases globally.
