Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Oct 26, 2025; 17(10): 110248
Published online Oct 26, 2025. doi: 10.4252/wjsc.v17.i10.110248
Published online Oct 26, 2025. doi: 10.4252/wjsc.v17.i10.110248
Extracellular vesicles from adipose-derived stem cells in bone regeneration: Mechanisms and therapeutic advances
An Lin, Jia-Lu Yu, Sheng-Meng Yuan, Ke-Xin Yang, Yu-Hao Wang, Zhao-Rui Jin, Wei-Dong Tian, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Ying-Feng Tang, Chao Yang, Department of Research and Development, Chengdu Shilian
Fang-Jun Huo, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Qi Xiao, School of Bioscience and Technology, Chengdu Medical College, Chengdu 610500, Sichuan Province, China
Co-corresponding authors: Chao Yang and Wei-Dong Tian.
Author contributions: Lin A was responsible for the conceptual design, literature collection, manuscript writing, and overall coordination of the review; Yu JL contributed to literature analysis, figure preparation, and manuscript revision; Yuan SM, Tang YF, Yang KX, and Wang YH assisted with data interpretation and critical literature review; Huo FJ and Jin ZR contributed to the refinement of the manuscript; Xiao Q helped with reference management and formatting; Yang C and Tian WD supervised the entire project, provided critical revisions, and are the corresponding authors responsible for the final approval of the manuscript. Yang C and Tian WD are co-corresponding authors, the two co-corresponding authors contributed equally to this review, and their collaboration ensured the scientific rigor and integrity of the work. All authors read and approved the final version of the manuscript.
Supported by the National Key Research and Development Program of China, No. 2022YFA1104400; and the National Natural Science Foundation of China, No. U21A20369.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao Yang, Department of Research and Development, Chengdu Shiliankangjian Biotechnology Co., Ltd, No. 366 Hemin Street, Chengdu High-Tech Zone, Chengdu 610213, Sichuan Province, China. yangchao1207@qq.com
Received: June 3, 2025
Revised: July 17, 2025
Accepted: September 8, 2025
Published online: October 26, 2025
Processing time: 144 Days and 18.1 Hours
Revised: July 17, 2025
Accepted: September 8, 2025
Published online: October 26, 2025
Processing time: 144 Days and 18.1 Hours
Core Tip
Core Tip: Extracellular vesicles derived from adipose-derived stem cells exhibit significant potential in bone regeneration. They mediate osteogenesis, angiogenesis, and immunomodulation via bioactive molecules, with translational strategies including preconditioning, cargo engineering, and biomaterial integration. This review summarizes their efficacy in fractures, osteoarthritis, and osteoporosis, and discusses clinical translation challenges.