Adipose-derived regenerative therapies for the treatment of knee osteoarthritis

doi:10.4252/wjsc.v16.i4.324

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Apr 26, 2024 (publication date) through Feb 17, 2026

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2024; 16(4): 324-333
Published online Apr 26, 2024. doi: 10.4252/wjsc.v16.i4.324

Adipose-derived regenerative therapies for the treatment of knee osteoarthritis

Ilias E Epanomeritakis, Wasim S Khan

Ilias E Epanomeritakis, Division of Trauma and Orthopaedic Surgery, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom

Wasim S Khan, Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, United Kingdom

Author contributions: Epanomeritakis IE and Khan WS designed the overall concept and outline of the manuscript, contributed to the review of literature, and contributed to the writing and editing of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Wasim S Khan, FRCS, MBChB, MSc, PhD, Associate Professor, Surgeon, Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Hills Road, Cambridge CB2 0QQ, United Kingdom. wk280@cam.ac.uk

Received: January 17, 2024
Peer-review started: January 17, 2024
First decision: February 3, 2024
Revised: February 15, 2024
Accepted: March 1, 2024
Article in press: March 1, 2024
Published online: April 26, 2024
Processing time: 98 Days and 16.9 Hours

Core Tip

Core Tip: Adipose tissue products are becoming increasingly popular regenerative therapies for treating knee osteoarthritis. Encouraging results have been demonstrated in numerous observational studies and randomized trials. However, it is important to distinguish among isolated adipose-derived mesenchymal stromal cells (ASCs), stromal vascular fraction (SVF), and micro-fragmented adipose tissue (MFAT) to avoid study heterogeneity and improve the quality of evidence regarding these therapies. Different modes of preparation, cell composition, and physical properties are likely to influence the regenerative function of ASCs. To elucidate which adipose-derived therapy is superior for cartilage regeneration, randomized trials are needed to compare ASCs, SVF, and MFAT as distinct therapies.