Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Nov 26, 2024; 16(11): 974-977
Published online Nov 26, 2024. doi: 10.4252/wjsc.v16.i11.974
Resilience and challenges: Evaluating the impact of stress conditions on mesenchymal stem cells across different passages
Yue Ding, Fang Lin, Xiao-Ting Liang
Yue Ding, Department of Organ Transplantation, Naval Medical University, Shanghai 200000, China
Fang Lin, Shanghai Heart Failure Research Center, Shanghai East Hospital, Shanghai 200000, China
Xiao-Ting Liang, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200120, China
Xiao-Ting Liang, Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200000, China
Co-first authors: Yue Ding and Fang Lin.
Author contributions: Ding Y and Lin F contributed equally to the conceptualization and drafting of the manuscript, fulfilling the responsibilities of co-first authors; Liang XT provided review and edits to refine the manuscript. All authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81500207 to Xiao-Ting Liang; and the Pyramid Talent Project, No. YQ677 to Yue Ding.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Ting Liang, MD, PhD, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, No. 150 Jimo Road, Shanghai 200120, China. liangxt@tongji.edu.cn
Received: April 30, 2024
Revised: September 26, 2024
Accepted: October 31, 2024
Published online: November 26, 2024
Processing time: 210 Days and 7.4 Hours
Core Tip

Core Tip: This article discussed the research by Almahasneh et al on the resilience of mesenchymal stem cells (MSCs) under high glucose and severe hypoxia conditions at different passages. Highlighting the adaptability of higher passage MSCs, this study challenges traditional preferences for lower passage MSCs for use in clinical treatments, especially under conditions simulating diabetic or ischemic environments. While offering novel insights into MSC adaptability are offered, the research’s reliance on in vitro tests from a single cell line highlights the need for more in-depth in vivo studies to ascertain the clinical relevance of these findings and broaden their applicability.