Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Nov 26, 2024; 16(11): 926-943
Published online Nov 26, 2024. doi: 10.4252/wjsc.v16.i11.926
Yes-associated protein-mediated melatonin regulates the function of periodontal ligament stem cells under oxidative stress conditions
Ke Gu, Xiao-Mei Feng, Shao-Qing Sun, Xing-Yao Hao, Yong Wen
Ke Gu, Xiao-Mei Feng, Shao-Qing Sun, Xing-Yao Hao, Yong Wen, Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, No. 44-1 Wenhua Road West, Jinan 250012, Shandong Province, China
Ke Gu, Stomatological Hospital, School of Medicine, Nankai University, Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China
Co-first authors: Ke Gu and Xiao-Mei Feng.
Author contributions: Gu K and Feng XM contributed equally to the manuscript, they are the co-first authors of this manuscript; Feng XM and Wen Y conceived and designed the research; Gu K, Sun SQ, and Hao XY performed the research and acquired the data; Gu K assembled the figures. All authors contributed to the analysis and interpretation of the data and were involved in drafting and revising the manuscript. All authors have read and approved the final manuscript.
Supported by Open Foundation of Shandong Key Laboratory of Oral Tissue Regeneration, No. SDDX202001; Shandong Provincial Natural Science Foundation, No. ZR2021MH075; and Clinical Research Center of Shandong University, No. 2020SDUCRCC006.
Institutional review board statement: This study was approved by the Research Ethics Committee of Shandong University (No. GR201902).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong Wen, Doctor, PhD, Professor, Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, No. 44 Wenhua West Road, No. 44-1 Wenhua Road West, Jinan 250012, Shandong Province, China. wenyong@sdu.edu.cn
Received: March 4, 2024
Revised: August 20, 2024
Accepted: September 6, 2024
Published online: November 26, 2024
Processing time: 266 Days and 19.9 Hours
Core Tip

Core Tip: While the use of mesenchymal stem cells in preclinical and clinical studies for the treatment of various diseases has provided promising results, the microenvironment of oxidative stress inhibits the efficacy of mesenchymal stem cells-mediated tissue regeneration, which remains a major challenge limiting clinical applications. Our findings provide new insights into melatonin (MT) regulation in the biological functions of oxidative stress-induced periodontal ligament stem cells and elucidate the potential mechanism of Yes-associated protein-mediated MT action. These findings strengthen our comprehension of the role of MT during cellular oxidative stress and provide potential targets for the development of new therapeutic strategies to promote tissue regeneration.