Copyright
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Nov 26, 2024; 16(11): 900-905
Published online Nov 26, 2024. doi: 10.4252/wjsc.v16.i11.900
Published online Nov 26, 2024. doi: 10.4252/wjsc.v16.i11.900
Potential of ginsenoside Rg1 to treat aplastic anemia via mitogen activated protein kinase pathway in cyclophosphamide-induced myelosuppression mouse model
See-Hyoung Park, Biological and Chemical Engineering, Hongik University, Sejong 30016, South Korea
Author contributions: Park SH designed the overall concept and outline of the manuscript; Park SH contributed to the discussion and design of the manuscript, the writing, editing, and reviewing the manuscript.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: See-Hyoung Park, Associate Professor, PhD, Biological and Chemical Engineering, Hongik University, Sejongro 2639, Sejong 30016, South Korea. shpark74@hongik.ac.kr
Received: August 21, 2024
Revised: October 12, 2024
Accepted: November 20, 2024
Published online: November 26, 2024
Processing time: 97 Days and 6 Hours
Revised: October 12, 2024
Accepted: November 20, 2024
Published online: November 26, 2024
Processing time: 97 Days and 6 Hours
Core Tip
Core Tip: An animal model of aplastic anemia was established in mice using cyclophosphamide, and pathological changes in the bone marrow were analyzed using hematoxylin-eosin staining of the tissues. Blood samples were collected from the mice to analyze blood cell composition. This study also examined the changes in cellular components and protein expression in the mitogen activated protein kinase signaling pathway within the bone marrow to determine whether ginsenoside Rg1 can mitigate myelosuppression through the mitogen activated protein kinase pathway.