Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2023; 15(8): 842-865
Published online Aug 26, 2023. doi: 10.4252/wjsc.v15.i8.842
Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis
Wen-Jie Zhao, Xin Liu, Man Hu, Yu Zhang, Peng-Zhi Shi, Jun-Wu Wang, Xu-Hua Lu, Xiao-Fei Cheng, Yu-Ping Tao, Xin-Min Feng, Yong-Xiang Wang, Liang Zhang
Wen-Jie Zhao, Man Hu, Peng-Zhi Shi, Graduate School, Dalian Medical University, Dalian 116044, Liaoning Province, China
Xin Liu, Yu Zhang, Jun-Wu Wang, Yu-Ping Tao, Xin-Min Feng, Yong-Xiang Wang, Liang Zhang, Department of Orthopedics, Clinical Medical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Xu-Hua Lu, Department of Orthopedics, Changzheng Hospital of The Second Military Medical University, Shanghai 200003, China
Xiao-Fei Cheng, Department of Orthopedic Surgery, Shanghai Key Laboratory of Orthopedics Implants, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
Author contributions: Zhao WJ and Liu X contributed to data curation, Writing-Original draft preparation, contributed equally to this work; Hu M and Zhang Y contributed to Visualization, Validation; Shi PZ and Wang JW performed Investigation; Lu XH, Cheng XF and Tao YP performed conceptualization, methodology; Feng XM, Wang YX and Zhang L performed supervision, writing- reviewing, editing and share corresponding author.
Supported by the National Natural Science Foundation of China, No. 82172462 and No. 81972136; the Traditional Chinese Medicine Science and Technology Development Plan Project of Jiangsu Province, No. YB2020085; and Cross Cooperation Project of Northern Jiangsu People’s Hospital, No. SBJC21014.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals, Yangzhou University, No. SYXK (Su) 2017-0044.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. Figures 12A and 13 were created using Figdraw (www.figdraw.com).
Data sharing statement: All data during the study are available from the corresponding author by request at zhangliang6320@sina.com.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Liang Zhang, PhD, Professor, Department of Orthopedics, Clinical Medical College, Yangzhou University, No. 98 Nantong West Road, Yangzhou, 225001, Jiangsu Province, China. zhangliang6320@sina.com
Received: April 18, 2023
Peer-review started: April 18, 2023
First decision: May 17, 2023
Revised: May 25, 2023
Accepted: June 27, 2023
Article in press: June 27, 2023
Published online: August 26, 2023
Processing time: 129 Days and 0.1 Hours
Core Tip

Core Tip: In our article, we provide the evidence that quercetin (Que) can prevent oxidative stress induced senescence of nucleus pulposus-derived mesenchymal stem cells via miR-34a/SIRT1 signaling pathway. Moreover, Que could ameliorate the progression of intervertebral disc degeneration (IDD) in rat model. Thus, Que can be considered as a potential agent for the treatment of IDD.