Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2023; 15(6): 548-560
Published online Jun 26, 2023. doi: 10.4252/wjsc.v15.i6.548
Factors affecting osteogenesis and chondrogenic differentiation of mesenchymal stem cells in osteoarthritis
Yi Peng, Hai Jiang, Hou-Dong Zuo
Yi Peng, Hai Jiang, Hou-Dong Zuo, Medical Imaging Key Laboratory of Sichuan Province, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Hou-Dong Zuo, Department of Radiology, Chengdu Xinhua Hospital, Chengdu 610067, Sichuan Province, China
Author contributions: Yi P wrote the paper; Hai J reviewed the literature; Zuo HD designed the outline and coordinated the writing of the paper; and all authors have read and approved the final manuscript.
Supported by the Nature Science Foundation of China, No. 81701756; Sichuan Provincial Department of Education, No. 18ZB0215; City-School Cooperation Project, No. 18SXHZ0389 and No. 22SXZRKX0005; and Chengdu Medical Project, No. 2022573.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hou-Dong Zuo, MD, Doctor, Teacher, Medical Imaging Key Laboratory of Sichuan Province, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan South Road, Shunqing District, Nanchong 637000, Sichuan Province, China. zuohoud@163.com
Received: March 17, 2023
Peer-review started: March 17, 2023
First decision: April 10, 2023
Revised: April 21, 2023
Accepted: May 5, 2023
Article in press: May 5, 2023
Published online: June 26, 2023
Processing time: 101 Days and 0.8 Hours
Core Tip

Core Tip: Several reviews have summarized the current status of mesenchymal stem cells (MSCs) in the treatment of osteoarthritis (OA). These studies usually focus on the paracrine function of MSCs. However, the differentiation function of MSCs also plays an important role in the treatment of diseases. This is the first review to report the factors that may affect the differentiation direction of MSCs in the treatment of OA and aims to provide guidance for more accurate regulation when MSC therapy is applied in the future.