Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2021; 13(12): 1905-1917
Published online Dec 26, 2021. doi: 10.4252/wjsc.v13.i12.1905
Bone marrow mesenchymal stem cell therapy regulates gut microbiota to improve post-stroke neurological function recovery in rats
Lin-Na Zhao, Song-Wen Ma, Jie Xiao, Li-Ji Yang, Shi-Xin Xu, Lan Zhao
Lin-Na Zhao, Song-Wen Ma, Jie Xiao, Li-Ji Yang, Shi-Xin Xu, Lan Zhao, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
Lin-Na Zhao, Song-Wen Ma, Jie Xiao, Li-Ji Yang, Shi-Xin Xu, Lan Zhao, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Lin-Na Zhao, Shi-Xin Xu, Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin 300381, China
Author contributions: Zhao LN and Zhao L drafted and wrote the paper; Ma SW and Xiao J performed the experiments; Yang LJ performed the statistical analysis; Xu SX contributed to designing the experiments and revising the article.
Supported by National Natural Science Foundation of China, No. 81774059 and No. 82074533; Tianjin Natural Science Foundation, No. 19JCZDJC37100.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Experimental Animal Ethics Committee of Tianjin University of Traditional Chinese Medicine (IACUC protocol number: [Protocol No. TCM-LAEC2019038]).
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lan Zhao, PhD, Research Fellow, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Chang Ling Road, Xi Qing District, Tianjin 300381, China. lanzhao69@163.com
Received: May 5, 2021
Peer-review started: May 5, 2021
First decision: June 23, 2021
Revised: July 6, 2021
Accepted: December 11, 2021
Article in press: December 11, 2021
Published online: December 26, 2021
Processing time: 233 Days and 23.4 Hours
Core Tip

Core Tip: Bone marrow mesenchymal stem cell (BMSC) transplantation provides a novel approach for ischemic stroke therapy. Studies on the “gut-brain axis” indicate that gut microbiota dysbiosis affects stroke prognosis. We investigated the interactions between BMSCs and gut microbiota. Our findings indicate that the therapeutic mechanism of BMSCs on ischemic stroke treatment may involve the regulation of microbiome structure and function.