Exosomes derived from inflammatory myoblasts promote M1 polarization and break the balance of myoblast proliferation/differentiation
Zhi-Wen Luo, Ya-Ying Sun, Jin-Rong Lin, Bei-Jie Qi, Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
Ji-Wu Chen, Department of Sports Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Author contributions: Chen JW, Luo ZW, and Sun YY designed and performed most of the experiments, analyzed and interpreted the data, and wrote the manuscript; Luo ZW and Lin JR assisted during the acquisition, analysis, and interpretation of data and revised the manuscript; Luo ZW, Qi BJ, and Sun YY assisted with data acquisition and revision of the manuscript; all authors have reviewed and approved the final version of the manuscript; Luo ZW and Sun YY contributed equally to this study.
Supported by National Natural Science Foundation of China, No. 81772419 and No. 81972062.
Institutional animal care and use committee statement: The experiments in this study were approved by Huashan Hospital, Fudan University, No. 20171248A703.
Conflict-of-interest statement: The authors declare that they have no competing interests, and all authors should confirm its accuracy.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Ji-Wu Chen, MD, PhD, Academic Research, Chief Doctor, Professor, Department of Sports Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
jeevechen@gmail.com
Received: May 1, 2021
Peer-review started: May 1, 2021
First decision: June 16, 2021
Revised: June 28, 2021
Accepted: September 2, 2021
Article in press: September 2, 2021
Published online: November 26, 2021
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