Systematic Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Nov 26, 2019; 11(11): 1005-1019
Published online Nov 26, 2019. doi: 10.4252/wjsc.v11.i11.1005
In vitro differentiation capacity of human breastmilk stem cells: A systematic review
Camila Maria Ribeiro Pacheco, Priscila Elias Ferreira, Claudia Sayuri Saçaki, Luana Alves Tannous, Idiberto José Zotarelli-Filho, Luiz Cesar Guarita-Souza, Katherine Athayde Teixeira de Carvalho
Camila Maria Ribeiro Pacheco, Priscila Elias Ferreira, Claudia Sayuri Saçaki, Katherine Athayde Teixeira de Carvalho, Cell Therapy and Biotechnology in Regenerative Medicine Department, Pelé Pequeno Príncipe Institute, Child and Adolescent Health Research and Pequeno Príncipe Faculty, Curitiba 80.240-020, Paraná, Brazil
Luana Alves Tannous, Luiz Cesar Guarita-Souza, PUCPR-Institute of Biological and Health Sciences, CCBS, Curitiba 80.215-901, Paraná, Brazil
Idiberto José Zotarelli-Filho, Post Graduate and Continuing Education (Unipos), Department of Scientific Production, São José do Rio Preto 15.020-040, São Paulo, Brazil
Author contributions: Pacheco CMR collected the data and drafted this manuscript; Ferreira PE collected the data and revised references; Saçaki CS collected the data; Tannous LA revised the draft; Zotarelli-Filho IJ revised the Prisma 2009; Guarita-Souza LC proposed some discussions in this work; de Carvalho KAT designed the systematic review and performed the data analysis; All authors read and approved the final manuscript.
Supported by Araucária Foundation (Paraná State-Brazil); and the Coordination for the Improvement of Higher Education Personnel-Brazil (Capes), Financial code 001
Conflict-of-interest statement: The authors have no potential conflicts of interests to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Katherine Athayde Teixeira de Carvalho, MD, MsC, PhD, Professor, Cell Therapy and Biotechnology in Regenerative Medicine Department, Pelé Pequeno Príncipe Institute, Child and Adolescent Health Research and Pequeno Príncipe Faculty, Ave. Silva Jardim, n°1632, Curitiba 80.240-020, Paraná, Brazil. katherinecarv@gmail.com
Received: April 3, 2019
Peer-review started: April 4, 2019
First decision: June 6, 2019
Revised: July 17, 2019
Accepted: September 4, 2019
Article in press: September 4, 2019
Published online: November 26, 2019
Processing time: 215 Days and 23.7 Hours
Core Tip

Core tip: Human breastmilk stem cells present interesting features that make them an alternative source of stem cells, mainly because they do not require any invasive procedure to be obtained. The objective was to investigate the literature data on their ability to differentiate into other cell lines. It was possible to verify that these cells have a high capacity of differentiation, as they are able to generate cells of the endoderm, mesoderm, and ectoderm lineages. However, the number of publications on the subject is still scarce, demonstrating that this source needs more studies and has the potential to be explored in regenerative medicine.