Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2024; 16(4): 459-461
Published online Apr 26, 2024. doi: 10.4252/wjsc.v16.i4.459
Reveal more mechanisms of precondition mesenchymal stem cells inhibiting inflammation
Yi Li, Qian-Qian Chen, En-Qiang Linghu
Yi Li, Qian-Qian Chen, Department of Gastroenterology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
En-Qiang Linghu, Department of Gastroenterology and Hepatology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Li Y wrote the manuscript; Chen QQ and Linghu EQ revised the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qian-Qian Chen, MD, Associate Chief Physician, Associate Professor, Department of Gastroenterology, First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. qian_qian_chen@163.com
Received: January 8, 2024
Peer-review started: January 8, 2024
First decision: March 9, 2024
Revised: March 12, 2024
Accepted: March 27, 2024
Article in press: March 27, 2024
Published online: April 26, 2024
Processing time: 107 Days and 21.3 Hours
Abstract

Hypoxia can get more ability to inhibit inflammation. But how it impact on survival time of mesenchymal stem cells (MSCs) is confusing and how preconditioned MSCs inhibiting inflammation are partially known. Those issues decided the value of preconditioned MSCs by hypoxia.

Keywords: Mesenchymal stem cell; Hypoxia-inducible factor 1α; Hypoxia; Inflammation; Macrophage

Core Tip: Precondition of mesenchymal stem cells (MSCs) can change the characteristic of MSCs and enhance its biological activity in specific aspects. Both hypoxia and the over-expression of hypoxia-inducible factor 1α can inhibit inflammation. But more mechanisms on precondition MSCs inhibiting inflammation should be revealed to promote curative effect.