Ding Y, Lin F, Liang XT. Innovative hydrogel delivery of bone marrow stromal cell-derived exosomes for enhanced bone healing. World J Stem Cells 2024; 16(12): 1106-1109 [PMID: PMC11669989 DOI: 10.4252/wjsc.v16.i12.1106]
Corresponding Author of This Article
Xiao-Ting Liang, MD, PhD, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, No. 150 Jimo Road, Shanghai 200120, China. liangxt@tongji.edu.cn
Research Domain of This Article
Cell & Tissue Engineering
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Dec 26, 2024; 16(12): 1106-1109 Published online Dec 26, 2024. doi: 10.4252/wjsc.v16.i12.1106
Innovative hydrogel delivery of bone marrow stromal cell-derived exosomes for enhanced bone healing
Yue Ding, Fang Lin, Xiao-Ting Liang
Yue Ding, Xiao-Ting Liang, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200120, China
Yue Ding, Department of Organ Transplantation, Naval Medical University, Shanghai 200000, China
Fang Lin, Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China
Co-first authors: Yue Ding and Fang Lin.
Author contributions: Ding Y and Lin F contributed equally to this work and as co-first authors of this manuscript. Ding Y, Lin F, and Liang XT wrote the original draft; Liang XT contributed to reviewing and editing the manuscript. All the authors have read and approved the manuscript.
Supported by the National Natural Science Foundation of China, No. 81500207; and the Pyramid Talent Project, China, No. YQ677.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Ting Liang, MD, PhD, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, No. 150 Jimo Road, Shanghai 200120, China. liangxt@tongji.edu.cn
Received: June 11, 2024 Revised: October 2, 2024 Accepted: November 29, 2024 Published online: December 26, 2024 Processing time: 184 Days and 23.1 Hours
Abstract
Bone regeneration is a multifaceted process involving the well-coordinated interaction of cellular functions such as the regulation of inflammation, the formation of new blood vessels, and the development of bone tissue. Bone regeneration is a multifaceted process involving the well-coordinated interplay of multiple cellular activities, such as inflammation control, blood vessel and bone tissue. Zhang et al developed a multifunctional hydrogel system embedded with bone marrow stromal cell-derived exosomes to address the challenges of large bone defects. This innovative approach demonstrated the dual-role capability of bone marrow stromal cell-derived exosomes in directing cell fate by significantly enhancing both angiogenesis and osteogenic differentiation in vitro. The hydrogel system effectively promoted the polarization of macrophages towards the anti-inflammatory M2 phenotype, fostering an environment that supports bone repair. The effectiveness of this hydrogel was validated in a murine fracture model, which promoted significant bone regeneration and functional vascularization. Despite compelling evidence, this study highlights areas for further investigation, including detailed descriptions of experimental procedures, control group selection, long-term outcomes, and the evaluation of inflammation status in vivo. Addressing these limitations will enhance the robustness and impact of the findings.
Core Tip: This study introduces a novel hydrogel system embedded with bone marrow stromal cell-derived exosomes that enhances bone regeneration by modulating inflammation and promoting angiogenesis. The dual-role capability of bone marrow stromal cell-derived exosomes in directing cell fate is a significant innovation, demonstrating enhanced angiogenesis and osteogenic differentiation. When validated in a murine fracture model, this approach showed promising potential for clinical application in the treatment of large bone defects. Further detailed investigations are needed to fully understand the therapeutic potential of this innovative strategy.
