Qin HC, Luo ZW, Zhu YL. Physical energy-based ultrasound shifts M1 macrophage differentiation towards M2 state. World J Stem Cells 2022; 14(2): 214-218 [PMID: 35432733 DOI: 10.4252/wjsc.v14.i2.214]
Corresponding Author of This Article
Yu-Lian Zhu, MD, PhD, Chief Doctor, Doctor, Professor, Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, No. 12 Wulumuqi Road, Shanghai 200040, China. zyljully@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Feb 26, 2022; 14(2): 214-218 Published online Feb 26, 2022. doi: 10.4252/wjsc.v14.i2.214
Physical energy-based ultrasound shifts M1 macrophage differentiation towards M2 state
Hao-Cheng Qin, Zhi-Wen Luo, Yu-Lian Zhu
Hao-Cheng Qin, Yu-Lian Zhu, Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
Zhi-Wen Luo, Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
Author contributions: Qin HC and Luo ZW conducted the original search, wrote the first draft of the paper, and contributed to subsequent revisions of the manuscript; Zhu YL generated the original idea of this study and provided suggestions; Qin HC and Luo ZW made equal contributions to the work.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Lian Zhu, MD, PhD, Chief Doctor, Doctor, Professor, Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, No. 12 Wulumuqi Road, Shanghai 200040, China. zyljully@163.com
Received: November 5, 2021 Peer-review started: November 5, 2021 First decision: December 4, 2021 Revised: December 12, 2021 Accepted: February 16, 2022 Article in press: February 16, 2022 Published online: February 26, 2022 Processing time: 111 Days and 21 Hours
Abstract
Recently, we read with interest the article entitled “Unveiling the Morphogenetic Code: A New Path at the Intersection of Physical Energies and Chemical Signaling”. In this paper, the investigation into the systematic and comprehensive bio-effects of physical energies prompted us to reflect on our research. We believe that ultrasound, which possesses a special physical energy, also has a certain positive regulatory effect on macrophages, and we have already obtained some preliminary research results that support our hypothesis.
Core Tip: Because physical energies can contribute to the recovery of tissue damage in multiple aspects, it is widely used in clinical practice. The unique insights of the article “Unveiling the Morphogenetic Code: A New Path at the Intersection of Physical Energies and Chemical Signaling” inspired the direction of our experiments concerning the impact of physical energies on stem cells. In the future, we will conduct experiments and analytical techniques to reveal the mechanism of the regulatory effects behind ultrasound.
