Therapeutic applications of adipose-derived stromal vascular fractions in osteoarthritis

doi:10.4252/wjsc.v14.i10.744

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 14, Issue 10

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (9976)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-2) series.

Item

Count

PDF

376

WORD

HTML

4576

Figures (1-1)

591

Tables (1-2)

471

Sum=6070

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

461

Download

1245

Sum=1706

Publishing Process of This Article

Item

Count

Browse

630

Download

1560

Sum=2190

Oct 26, 2022 (publication date) through Feb 17, 2026

Times Cited of This Article

Times Cited (11)

Journal Information of This Article

Publication Name

World Journal of Stem Cells

ISSN

1948-0210

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Minireviews

World J Stem Cells. Oct 26, 2022; 14(10): 744-755
Published online Oct 26, 2022. doi: 10.4252/wjsc.v14.i10.744

Therapeutic applications of adipose-derived stromal vascular fractions in osteoarthritis

Qi Tang, Xian-Sheng Zhao, Ao Guo, Ruo-Tong Cui, Huai-Le Song, Zi-Yang Qi, Yi Pan, Yue Yang, Fang-Fang Zhang, Liang Jin

Qi Tang, Ao Guo, Ruo-Tong Cui, Huai-Le Song, Zi-Yang Qi, Yi Pan, Yue Yang, Fang-Fang Zhang, Liang Jin, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, China

Xian-Sheng Zhao, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China

Author contributions: Tang Q and Zhao XS contributed data collection and manuscript writing; Guo A, Cui RT, Song HL, Qi ZY, Pan Y, Yang Y contributed data analysis; Zhang FF, Jin L contributed study design and supervision; all authors have read and approve the final manuscript.

Supported by National Natural Science Foundation of China, No. 82070801, No. 82100858, No. 82073227; China Postdoctoral Science Foundation, No. 2020M671661; Jiangsu Province Science Foundation for Youths, No. BK20200569; and Jiangsu Province Research Founding for Postdoctoral, No. 1412000016.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Liang Jin, PhD, Professor, School of Life Science and Technology, China Pharmaceutical University, No. 24 Tongjiaxiang Avenue, Nanjing 211198, Jiangsu Province, China. ljstemcell@cpu.edu.cn

Received: April 6, 2022
Peer-review started: April 6, 2022
First decision: June 22, 2022
Revised: July 8, 2022
Accepted: September 12, 2022
Article in press: September 12, 2022
Published online: October 26, 2022
Processing time: 201 Days and 20.6 Hours

Abstract

Osteoarthritis (OA) is considered to be a highly heterogeneous disease with progressive cartilage loss, subchondral bone remodeling, and low-grade inflammation. It is one of the world's leading causes of disability. Most conventional clinical treatments for OA are palliative drugs, which cannot fundamentally cure this disease. The stromal vascular fraction (SVF) from adipose tissues is a heterogeneous cell population. According to previous studies, it contains a large number of mesenchymal stem cells, which have been used to treat OA with good therapeutic results. This safe, simple, and effective therapy is expected to be applied and promoted in the future. In this paper, the detailed pathogenesis, diagnosis, and current clinical treatments for OA are introduced. Then, clinical studies and the therapeutic mechanism of SVF for the treatment of OA are summarized.

Keywords: Arthritis; Articular cartilage; Stromal vascular fraction; Mesenchymal stem cells; Cell therapy

Core Tip: Osteoarthritis (OA) is one of the world's leading causes of disability. Clinically, palliative drugs cannot fundamentally cure this disease. The stromal vascular fraction (SVF) from adipose tissues is a heterogeneous cell population. According to studies, it contains a large number of mesenchymal stem cells, which have been used to treat OA with good therapeutic effects. In this review, we present an updated status of the comprehensive and systematic review of pathogenesis, diagnosis, and current clinical treatments for OA, especially focusing on therapeutic applications of adipose-derived SVF.