Published online Apr 26, 2021. doi: 10.4252/wjsc.v13.i4.304
Peer-review started: October 14, 2020
First decision: December 12, 2020
Revised: December 26, 2020
Accepted: February 25, 2021
Article in press: February 25, 2021
Published online: April 26, 2021
Processing time: 189 Days and 18.2 Hours
Orthobiologics are biological materials that are intended for the regeneration or healing of bone, cartilage and soft tissues. In this review we discuss the use of orthobiologics for hip disorders providing an update. The orthobiologics included in this article are hyaluronic acid, platelet rich plasma, bone marrow, adipose tissue and expanded mesenchymal stem cells. We explain the concepts and definitions of each orthobiological product, and the literature regarding its use in the hip joint. The paucity of guidelines for the production and characterization of the biological products leads to uneven results across the literature. Each biologic therapy has indications and benefits; however, noteworthy are the characterization of the orthobiologics, the application method and outcome analysis for further improvement of each technique.
Core Tip: Orthobiologics are biological materials that are intended for the regeneration or healing of bone, cartilage and soft tissues. Commonly discussed orthobiologics include hyaluronic acid, platelet-rich plasma, bone marrow, adipose tissue and expanded mesenchymal stem cells. We explain the concepts and definitions of each orthobiologic and the literature regarding use for the hip joint. Each biological therapy has its own benefits and indications; however, it is important to note that the characterization of orthobiologics, injection method and evaluation analysis are of major importance for the use of biological therapies.