Enteroscopy and ablation of small bowel angiodysplasia improves quality-of-life and fatigue: A prospective study including biomarker assessment

doi:10.3748/wjg.v32.i18.117264

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May 14, 2026 (publication date) through May 6, 2026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. May 14, 2026; 32(18): 117264
Published online May 14, 2026. doi: 10.3748/wjg.v32.i18.117264

Table 1 Quality of life domain scores at base line and follow up, mean/median

Domain	PF	RL-P	RL-E	E/F	MH	SF	Pain	GH
Baseline	44.8/40	23.6/0	50.5/33	34.8/45	65.2/68	63.1/63	55.6/65	45.3/46
Follow up	62.4/65	54.8/50	66.7/100	54/50	84.1/92	90.7/100	61.2/60	63.4/65
Δ Mean (95%CI)	17.5 (8-27)	31.2 (6-57)	16.2 (-8 to 40)	19.2 (8-31)	18.7 (9-29)	27.7 (16-40)	5.6 (-11 to 23)	18 (10-26)
P value	0.003	0.017	0.178	0.002	0.001	0.0001	0.52	0.0001

PF: Physical functioning; RL-P: Role limitation physical; RL-E: Role limitation emotional; E/F: Energy/fatigue; MH: Mental health; SF: Social functioning; GH: General health; CI: Confidence interval.

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Table 2 Demographics and haemoglobin impact on change in significant quality of life domains and fatigue severity scale

Domain	Predictor	Coefficient	P value	CI lower	CI upper	R²d
PF change¹	Age	0.496799029	0.5493559	-1.1865686	2.18016665	0.048581685
PF change	Gender	7.609259284	0.5615835	-18.989681	34.2082	0.048581685
PF change	Hb	1.963534859	0.4963046	-3.8858508	7.81292048	0.048581685
RLP change	Age	-0.144349859	0.9149046	-2.894301	2.60560127	0.246642284
RLP change	Gender	36.69853355	0.0943931	-6.7535241	80.1505912	0.246642284
RLP change	Hb	7.170977096	0.1350192	-2.3845854	16.7265396	0.246642284
EF change	Age	0.946169468	0.2363515	-0.6583037	2.55064259	0.059013684
EF change	Gender	-5.636567085	0.6514632	-30.988894	19.7157594	0.059013684
EF change	Hb	1.086581889	0.6919798	-4.4886602	6.66182399	0.059013684
GH change	Age	-0.894963168	0.1269223	-2.0616117	0.27168537	0.101928309
GH change	Gender	5.985909667	0.5103566	-12.448338	24.420157	0.101928309
GH change	Hb	-2.06762978	0.3041048	-6.1215138	1.98625427	0.101928309
MH change	Age	-0.607081002	0.3391156	-1.8884905	0.67432848	0.212102758
MH change	Gender	21.07520033	0.0419478	0.82761193	41.3227887	0.212102758
MH change	Hb	0.489064312	0.823144	-3.9635924	4.94172105	0.212102758
SF change	Age	-0.390959905	0.6266197	-2.0232674	1.24134754	0.135090432
SF change	Gender	20.2213016	0.1191332	-5.5708357	46.0134389	0.135090432
SF change	Hb	1.068574657	0.7017204	-4.6033865	6.74053578	0.135090432
FSS change	Age	0.312632	0.531044	-0.70421	1.329473	0.158169
FSS change	Gender	7.96919	0.30262	-7.66476	23.60314	0.158169
FSS change	Hb	2.272987	0.188219	-1.19423	5.740201	0.158169

¹Difference in score from baseline and follow up.

PF: Physical functioning; RLP: Role limitation physical; EF: Energy fatigue; MH: Mental health; GH: General health; SF: Social functioning; FSS: Fatigue Severity Scale; Hb: Haemoglobin; CI: Confidence interval.

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Table 3 Angiogenic factor results for the cohort

Factor (dilution), pg/mL	Mean	Median	SD	95%CI
Endostatin (1/5)	2773.3	2763.9	417.3	2620-2926
Ang-1 (1/2)	598.8	497.9	394.8	435.9-743.64
Ang-2 (1/50)	15231.7	11514.5	11285.32	11092.3-19371.3
VEGF (1/2)	233.8	108.4	349.3	105.7-362.02
Timp-1 (1/500)	107269.3	78567.1	69069.6	81934.4-132604.2

Ang-1: Angiopoietin 1; Ang-2: Angiopoietin 2; VEGF: Vascular endothelial growth factor; Timp-1: Tissue inhibitor of metalloproteinases-1; CI: Confidence interval.

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Table 4 Demographics and angiogenic factor association

Angiogenic factor (dilution), pg/mL	Predictor	Coefficient	P value	R²
Ang-1 (1/2)	Age	-3.9091	0.6688	0.2064
Ang-1 (1/2)	Gender	170.7615	0.2425	0.2064
Ang-1 (1/2)	Hb	-79.3965	0.0178	0.2064
Ang-2 (1/50)	Age	45.1366	0.8759	0.0428
Ang-2 (1/50)	Gender	3435.2961	0.4542	0.0428
Ang-2 (1/50)	Hb	480.0491	0.6333	0.0428
VEGF (1/2)	Age	3.3534	0.6846	0.1569
VEGF (1/2)	Gender	98.5417	0.4517	0.1569
VEGF (1/2)	Hb	48.1964	0.1012	0.1569
Endostatin (1/5)	Age	-2.7524	0.8002	0.0332
Endostatin (1/5)	Gender	66.3708	0.6996	0.0332
Endostatin (1/5)	Hb	20.2682	0.5926	0.0332
Timp1 (1/500)	Age	2216.3375	0.217	0.0677
Timp1 (1/500)	Gender	-17153.681	0.5408	0.0677
Timp1 (1/500)	Hb	3417.3353	0.5793	0.0677

Ang-1: Angiopoietin 1; Ang-2: Angiopoietin 2; VEGF: Vascular endothelial growth factor; Timp-1: Tissue inhibitor of metalloproteinases-1; CI: Confidence interval; Hb: Haemoglobin.

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Citation: Butler T, O’Hara F, Costigan C, Sihag S, Kripakaran D, McNamara D. Enteroscopy and ablation of small bowel angiodysplasia improves quality-of-life and fatigue: A prospective study including biomarker assessment. World J Gastroenterol 2026; 32(18): 117264
URL: https://www.wjgnet.com/1007-9327/full/v32/i18/117264.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i18.117264

Butler T, O’Hara F, Costigan C, Sihag S, Kripakaran D, McNamara D. Enteroscopy and ablation of small bowel angiodysplasia improves quality-of-life and fatigue: A prospective study including biomarker assessment. World J Gastroenterol 2026; 32(18): 117264 [DOI: 10.3748/wjg.v32.i18.117264]

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