Butler T, O’Hara F, Costigan C, Sihag S, Kripakaran D, McNamara D. Enteroscopy and ablation of small bowel angiodysplasia improves quality-of-life and fatigue: A prospective study including biomarker assessment. World J Gastroenterol 2026; 32(18): 117264 [DOI: 10.3748/wjg.v32.i18.117264]
Corresponding Author of This Article
Deirdre McNamara, Professor, TAGG Research Centre, Clinical Medicine, Tallaght University Hospital, Belgard Square North, Dublin D24 NR0A, Ireland. mcnamad@tcd.ie
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
May 14, 2026 (publication date) through May 6, 2026
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Butler T, O’Hara F, Costigan C, Sihag S, Kripakaran D, McNamara D. Enteroscopy and ablation of small bowel angiodysplasia improves quality-of-life and fatigue: A prospective study including biomarker assessment. World J Gastroenterol 2026; 32(18): 117264 [DOI: 10.3748/wjg.v32.i18.117264]
Thomas Butler, Trinity Academic Gastroenterology Group, Clinical Medicine, Trinity College Dublin, Dublin D02 PN40, Ireland
Thomas Butler, Department of Gastroenterology, Tallaght University Hospital, Dublin D02 PN40, Ireland
Fintan O’Hara, Conor Costigan, Sandeep Sihag, Deirdre McNamara, TAGG Research Centre, Clinical Medicine, Tallaght University Hospital, Dublin D24 NR0A, Ireland
Divya Kripakaran, TAGG Research Centre, Clinical Medicine, Trinity College Dublin, Dublin D02 XH97, Ireland
Author contributions: McNamara D designed the study, oversaw the laboratory investigations, analyzed the research, and prepared the paper; McNamara D, O’Hara F, Costigan C, and Sihag S performed clinical procedures and assessments relevant to the study; O’Hara F, Costigan C, and Sihag S were involved in patient recruitment, and contributed to the analysis and writing; Butler T and Kripakaran D performed the biomarker laboratory testing and analysis, and reviewed the relevant statistical section of the paper, in addition to collating and managing the research data base. All authors approved the final version to publish.
Institutional review board statement: The study was reviewed and approved by the St James’s Hospital/Tallaght University Hospital Research Ethics Committee Review Board, No. 2020-10 Chairman’s Action (37).
Clinical trial registration statement: Not applicable.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Corresponding author: Deirdre McNamara, Professor, TAGG Research Centre, Clinical Medicine, Tallaght University Hospital, Belgard Square North, Dublin D24 NR0A, Ireland. mcnamad@tcd.ie
Received: December 3, 2025 Revised: January 13, 2026 Accepted: February 13, 2026 Published online: May 14, 2026 Processing time: 154 Days and 19 Hours
Core Tip
Core Tip: This prospective study in subjects with small bowel angiodysplasia has demonstrated that endoscopic intervention with balloon assisted enteroscopy and argon plasma coagulation has a positive impact on both patients reported quality of life and fatigue severity. The beneficial affect is independent of age, gender and baseline haemoglobin levels. The study supports the use of balloon assisted enteroscopy and argon plasma coagulation as a cornerstone of small bowel angiodysplasia treatment, particularly for those with multiple lesions and those amenable to intervention, as benefit was demonstrated without adjunctive medical therapy. Endostatin would appear to be a potential biomarker for response and warrants additional investigation.
