Endocuff Vision-enhanced colonoscopy: Does it improve polyp detection?

Table 1 Inclusion and exclusion criteria

Inclusion

Exclusion

(1) Ability to provide informed consent; (2) ≥ 18 years of age; (3) Undergoing a colonoscopy for screening or surveillance matters by a gastroenterologist

(1) Inability to provide consent; (2) Use of anticoagulation and anti-platelet agents that precludes the removal of polyps; (3) Prior history or current active inflammatory bowel disease; (4) History of polyposis syndromes or hereditary non-polyposis colorectal cancer; (5) Acute diverticulitis; (6) Previous colon surgery (excluding appendectomy); (7) Diagnosis of toxic megacolon; (8) Radiation therapy to abdomen or pelvis; (9) Pregnancy/lactation; (10) History of stroke or ischemia in previous 3 months; (11) Being deemed high risk by the performing endoscopist; (12) Fecal immunochemical test positive; and (13) Poor bowel prep (defined as abandoning the procedure prior to or inability to intubate the cecum)

Table 2 Baseline demographic and clinical characteristics of study participants by cohort, n (%)

Category	Treatment cohort (n = 375)	Control cohort (n = 375)	Total (n = 750)
Age, years
18-30	4 (1.1)	4 (1.1)	8 (1.1)
31-50	88 (23.5)	88 (23.5)	176 (23.5)
51-65	171 (45.6)	171 (45.6)	342 (45.6)
66+	112 (29.9)	112 (29.9)	224 (29.9)
Sex
Male	234 (62.4)	218 (58.1)	452 (60.3)
Female	141 (37.6)	157 (41.9)	298 (39.7)
Time since last colonoscopy1, years
0-5	278 (74)	158 (74)	436 (73.7)
6-10	79 (21)	38 (18)	117 (19.8)
10+	15 (4)	15 (7)	30 (5.1)
First colonoscopy	143 (38)	68 (18)	211 (28.1)
Endoscopist distribution
Endoscopist A	26 (7)	49 (13)	75 (10)
Endoscopist B	203 (54)	131 (35)	334 (44.5)
Endoscopist C	90 (24)	120 (32)	225 (30)
Endoscopist D	105 (28)	120 (32)	225 (30)
Previous CRC	3 (1)	6 (2)	9 (1.2)

¹Time since last colonoscopy data available for n = 375 (treatment) and n = 214 (control).

CRC: Colorectal cancer.

Table 3 Polyp detection rate by cohort and endoscopist, %

Result	Treatment cohort (n = 375)	Control cohort (n = 375)	Percent change from control	P value
PDR	88.3	72.3
PDR by endoscopist
Endoscopist A	84	92	8.7% decrease	Not significant
Endoscopist B	75	86	12.8% decrease	Significant (P < 0.01, Bonferroni-adjusted)
Endoscopist C	63	86	26.7% decrease	Significant (P < 0.01, Bonferroni-adjusted)
Endoscopist D	76	91	16.5% decrease	Significant (P < 0.01, Bonferroni-adjusted)

PDR: Polyp detection rate.

Table 4 Tolerance of Endocuff-enhanced colonoscopy in the treatment cohort, n (%)

Tolerance	Treatment cohort (n = 375)
Excellent	355 (95)
Good	16 (4)
Poor	4 (1)