Endocuff Vision-enhanced colonoscopy: Does it improve polyp detection?

doi:10.3748/wjg.v32.i12.113927

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Mar 28, 2026 (publication date) through Mar 19, 2026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2026; 32(12): 113927
Published online Mar 28, 2026. doi: 10.3748/wjg.v32.i12.113927

Endocuff Vision-enhanced colonoscopy: Does it improve polyp detection?

Olivia Dupuis, Sebastian Mavromatis, Alexander Mavromatis, Christine Nadia Compas, Charles Sabbagh, Liliana Oliveira, Philip Hassard

Olivia Dupuis, Department of Anesthesia, University of Ottawa, Ottawa K1N 6N5, Ontario, Canada

Sebastian Mavromatis, Alexander Mavromatis, Department of Medicine, University of Sherbrooke, Sherbrooke J1H 5N4, Quebec, Canada

Christine Nadia Compas, Institute du Savoir Montfort, Montfort Hospital, Ottawa K1K 0T3, Ontario, Canada

Charles Sabbagh, Liliana Oliveira, Philip Hassard, Department of Medicine, University of Ottawa, Ottawa K1K 0T3, Ontario, Canada

Author contributions: Hassard P contributed to conceptualization and supervision; Dupuis O, Mavromatis S, Mavromatis A, and Hassard P contributed to methodology; Dupuis O, Mavromatis S, and Compas CN contributed to data collection; Dupuis O, Mavromatis S, Mavromatis A, Compas CN, and Hassard P contributed to formal analysis; Dupuis O, Mavromatis S, and Mavromatis A contributed to original draft preparation; all authors contributed to review and editing, and have read and agreed to the published version of the manuscript.

Institutional review board statement: This study was approved by the Montfort Hospital Research Ethics Board, No. 22-23-04-002.

Clinical trial registration statement: This study was registered at ClinicalTrials.gov, No. NCT05615857.

Informed consent statement: Written informed consent was obtained from all participants prior to participation in the study.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

CONSORT 2010 statement: This study did not conduct a randomized study, therefore, the consort 2010 checklist for randomized studies does not apply to this.

Data sharing statement: The data will be kept at Institute du Savoir Montfort and will be available on request. To have access to the identified data, a request to the privacy office will be mandatory.

Corresponding author: Philip Hassard, MD, Assistant Professor, Department of Medicine, University of Ottawa, 713 Montreal Road, Ottawa K1K 0T3, Ontario, Canada. philiphassard@montfort.on.ca

Received: September 8, 2025
Revised: November 9, 2025
Accepted: February 5, 2026
Published online: March 28, 2026
Processing time: 193 Days and 12.8 Hours

Abstract

BACKGROUND

Screening by colonoscopy plays a pivotal role in the decreasing incidence and mortality rates associated with colorectal cancer. However, studies continue to highlight significant miss rates in standard colonoscopy. To address this challenge, an endoscopic-assisting device, Endocuff-Vision, aims to enhance mucosal inspection and improve polyp detection. Although many studies have discovered promising results with the Endocuff, other large studies report inconsistent findings.

AIM

To evaluate the real-world effectiveness and safety profile of the Endocuff.

METHODS

We conducted a non-randomized prospective trial by recruiting consenting and eligible participants aged 18+ years (n = 375) undergoing a colonoscopy at the Montfort Hospital (Ontario, Canada). The Endocuff Vision was used in all colonoscopies. Primary outcomes assessed the Endocuff’s polyp detection rate compared to retrospective controls of standard colonoscopy dating up to 5 years. The control cohort (n = 375) was established by sample-matching. Secondary outcomes included safety and patient tolerance.

RESULTS

Colonoscopy with Endocuff in our study yielded a significantly lower overall polyp detection rate compared to controls (72.2% vs 88.7%, P < 0.01). The Endocuff device was well tolerated (94.7%), with no adverse events reported.

CONCLUSION

In this real-world study, Endocuff-enhanced colonoscopy was not superior to standard colonoscopy. Further larger scale studies with our population are required to validate findings.

Keywords: Polyp detection; Colonoscopy; Screening; Endocuff; Endocuff-Vision; Colon cancer

Core Tip: The Endocuff device has been previously shown to improve polyp detection in screening colonoscopy. We demonstrate in this study that in an experienced group of gastroenterologists the device did not improve polyp detection, possibly diminishing polyp detection for experienced endoscopists. While several limitations, the Endocuff did not offer a clinically meaningful improvement in polyp detection.