Anwei decoction alleviates chronic atrophic gastritis by modulating the gut microbiota-metabolite axis and NLRP3 inflammasome activity

doi:10.3748/wjg.v32.i1.113181

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 32, Issue 1

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (254)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-11) series, Tables (1-3) series.

Item

Count

PDF

HTML

Figures (1-11)

Tables (1-3)

Sum=136

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=107

Jan 7, 2026 (publication date) through Jan 12, 2026

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Jan 7, 2026; 32(1): 113181
Published online Jan 7, 2026. doi: 10.3748/wjg.v32.i1.113181

Table 1 Results of serum composition identification of Anwei decoction

No	Compound	Reference lon	Formula	RT/m	m/z (actual)	m/z (theoretical)	Annotation MW	Calculate MW	δ/ppm	Sort
1	Isoliquiritigenin[1]	[M+H]+1	C₁₅H₁₂O₄	12.241	257.08105	257.08054	256.07356	256.07378	0.00022	Flavonoids
2	Methyl succinic acid[2]	[M-H]-1	C₅H₈O₄	6.224	131.0338	131.03375	132.04226	132.04107	-0.00118	Dicarboxylic acid
3	4-oxoproline[3]	[M-H]-1	C₅H₇NO₃	2.761	128.03412	128.03406	129.04259	129.0414	-0.0012	Amino acids
4	Caffeic acid[4]	[M+H]+1	C₉H₈O₄	18.562	149.02344	179.03419	180.04226	148.01615	-32.02611	Phenolic acids
5	Citric acid[5]	[M-H]-1	C₆H₈O₇	3.046	191.01913	191.01883	192.027	192.02641	-0.00059	Tricarboxylic acids
6	2-phenoxypropanoic acid	[M+FA-H]-1	C₉H₁₀O₃	9.34	165.05478	165.05458	166.06299	120.05657	-46.00642	Carboxylic acids
7	Nor-9-carboxy-δ9-THC[6]	[M+H-H2O]+1	C₂₁H₂₈O₄	14.998	345.20596	345.20358	344.19876	362.20915	18.01039	Cannabinoids
8	(2E)-4-hydroxy-3,7-dimethyl-2,6-octadien-1-ylbeta-D-glucopyranoside	[M-H]-1	C₁₆H₂₈O₇	19.81	377.18655	377.18167	332.1835	378.19383	46.01033	Glycoside
9	1-[2-(1,3-Benzodioxol-5-yl)-3-methyl-1-benzofuran-5-yl]-1,2-propanediol	[M+H-H2O]+1	C₁₉H₁₈O₅	16.836	309.11191	309.11212	368.10962	368.1121	0.00248	Alcohols
10	Ethyl palmitoleate	[M+H]+1	C₁₈H₃₄O₂	20.671	283.26306	283.2634	282.25588	282.25578	-0.0001	Aliphatic
11	Gibberellin A7[7]	[M-H]-1	C₁₉H₂₂O₅	15.936	329.13959	329.13947	330.14672	330.14686	0.00014	Diterpenoids
12	(2R)-2-[(2R,5S)-5-[(2S)-2-hydroxybutyl] oxolan-2-yl] propanoic acid	[M+H]+1	C₁₁H₂₀O₄	13.463	217.14366	217.14362	216.13616	216.13638	0.00023	Carboxylic acids
13	Avocadyne 1-acetate[8]	[M+H]+1	C₁₉H₃₄O₄	19.822	309.24216	277.21643	326.24571	308.23502	-18.01068	Aliphatic
14	4-{[(3S)-3-{5-[4-(dimethyl amino) phenyl]-1,3,4-oxadiazol-2-yl}-1-pyrrolidinyl] methyl} benzoic acid	[M-H]-1	C₂₂H₂₄N₄O₃	17.359	391.17963	391.17639	392.18484	392.1869	0.00206	Heteroaromatic
15	6-acetylmorphine[9]	[M+H]+1	C₁₉H₂₁NO₄	8.764	328.15442	328.15405	327.14706	327.14714	0.00008	Morphinans
16	Methyl 3-(methylamino)-2-[(4-methyl-1,2,3-thiadiazol-5-yl)carbonyl] but-2-enoate	[M-H]-1	C₁₀H₁₃N₃O₃S	17.614	357.10123	357.10373	255.06776	358.1085	103.04074	Esters
17	4-(dimethylamino)-N-{[(2R,4S,5S)-5-(1-piperidinylmethyl)-1-azabicyclo[2.2.2] oct-2-yl]methyl} benzamide	[M+Na]+1	C₂₃H₃₆N₄O	22.502	367.28183	367.28198	384.28891	344.29257	-39.99635	Amides
18	2-hydroxymyristic acid	[M-H]-1	C₁₄H₂₈O₃	19.672	243.1964	243.19646	244.20384	244.20367	-0.00017	Long-chain fatty
19	4-(1-adamantyl)-2-methyl-1,3-thiazole	[M+H]+1	C₁₄H₁₉NS	8.375	234.13382	234.1333	233.12382	233.12635	0.00253	Thiazoles

The data in the third column of the table represents the ion mode of the compound. Determining the ion mode not only improves the accuracy and reliability of identification, but also provides adduct ion information, assists in molecular formula deduction, and obtains more comprehensive secondary mass spectrometry fragmentation information. MW: Molecular weight.

Full Size Table

Table 2 Quantitative histopathological scoring of gastric mucosa in each group, mean ± SD

Group	Chronic inflammation	Active inflammation	Glandular atrophy	Intestinal epithelial metaplasia
NC	0 ± 0	0 ± 0	0 ± 0	0 ± 0
MD	2.17 ± 0.41^b	0.33 ± 0.52^b	1.17 ± 0.41^b	0.33 ± 0.52^b
AWD	0.17 ± 0.37^b	0 ± 0^b	0 ± 0^b	0 ± 0^b
WFC	0.33 ± 0.52^a	0.33 ± 0.52	0 ± 0^b	0 ± 0^b

^aP < 0.05.

^bP < 0.01.

NC: Normal control; MD: Model; AWD: Anwei decoction; WFC: Weifuchun capsules.

Full Size Table

Table 3 Levels of inflammatory factors in gastric mucosa across experimental groups, mean ± SD

Group	IL-1β (pg/mg)	TNF-α (pg/mg)	IL-18 (pg/mg)	LPS (pg/mg)
NC	49.36 ± 7.36	86.46 ± 14.13	73.37 ± 10.74	348.38 ± 62.7
MD	122.7 ± 7.23^b	185.97 ± 18.5^b	143.86 ± 21.01^b	719.75 ± 87.54^b
AWD	62.69 ± 9.14^b	111.4 ± 19.05^b	90.99 ± 19.14^b	459.82 ± 99.02^b
WFC	80.08 ± 13.25^b	140.29 ± 13.05^b	120.98 ± 21.71^a	579.85 ± 74.8^a

^aP < 0.05.

^bP < 0.01.

NC: Normal control; MD: Model; AWD: Anwei decoction; WFC: Weifuchun capsules; IL: Interleukin; TNF: Tumor necrosis factor; LPS: Lipopolysaccharide.

Full Size Table

Citation: Qin H, Liu YY, Li Q, Wei SY, Huang LY, Zhou CF, Tan LY, Zhang JW, Wu DK, Tang YM. Anwei decoction alleviates chronic atrophic gastritis by modulating the gut microbiota-metabolite axis and NLRP3 inflammasome activity. World J Gastroenterol 2026; 32(1): 113181
URL: https://www.wjgnet.com/1007-9327/full/v32/i1/113181.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i1.113181