Copyright
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2026; 32(1): 113181
Published online Jan 7, 2026. doi: 10.3748/wjg.v32.i1.113181
Published online Jan 7, 2026. doi: 10.3748/wjg.v32.i1.113181
Anwei decoction alleviates chronic atrophic gastritis by modulating the gut microbiota-metabolite axis and NLRP3 inflammasome activity
Hong Qin, Yi-Yang Liu, Li-Yun Huang, Chai-Feng Zhou, Li-Yan Tan, Jing-Wen Zhang, Graduate School, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Auto
Qiang Li, Sai-Yan Wei, You-Ming Tang, Department of Digestive Disease, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
De-Kun Wu, Teaching Experiment and Training Center, Guangxi University of Chinese Medi
De-Kun Wu, Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
Co-first authors: Hong Qin and Yi-Yang Liu.
Co-corresponding authors: De-Kun Wu and You-Ming Tang.
Author contributions: Qin H, Liu YY wrote the manuscript and analyzed data; Li Q, Wei SY, Huang LY, Zhou CF, Tan LY, Zhang JW collected and assembled of data; Wu DK and Tang YM contributed to the article by providing critical guidance and revisions; all authors contributed to the study conception and design, they have read and approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 81860843; and Guangxi Administration of Traditional Chinese Medicine Project, No. GZSY23-36 and No. GXZYA20240150.
Institutional review board statement: This study does not involve any human experiments.
Institutional animal care and use committee statement: All experimental procedures complied rigorously with the Animal Ethics Code for Laboratory Welfare [animal use license No. SYXK (Gui) 2019-0001] and were officially authorized by the Animal Ethics Committee at Guangxi University of Traditional Chinese Medicine (approval No. DW20211117-178).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All data and original records can be obtained from the respective authors (1278323777@qq.com), and participants have given informed consent for data sharing.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: De-Kun Wu, MM, Associate Professor, Teaching Experiment and Training Center, Guangxi University of Chinese Medicine, No. 179 East Mingxiu Road, Xi
Received: August 25, 2025
Revised: October 3, 2025
Accepted: November 17, 2025
Published online: January 7, 2026
Processing time: 137 Days and 13 Hours
Revised: October 3, 2025
Accepted: November 17, 2025
Published online: January 7, 2026
Processing time: 137 Days and 13 Hours
Core Tip
Core Tip: Chronic atrophic gastritis (CAG) is a precancerous lesion of the stomach, with a prevalence of 34.7% in China and a risk of gastric cancer that is 4 times that of ordinary people. Existing therapies have high side effects and cannot reverse pathological damage. Traditional Chinese medicine Anwei decoction inhibits NLRP3 inflammasomes, reshapes the balance of microflora, breaks through the limitations of single targets, and provides a new strategy for CAG treatment, which can delay cancer and reverse pathological damage through the regulation of the “microbiota-metabolism-immunity” network.