Copyright
©The Author(s) 2020.
World J Gastroenterol. Jun 14, 2020; 26(22): 2948-2966
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.2948
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.2948
Type 1 DM | Type 2 DM | Type 3 DM | |
Pathogenesis | Chronic autoimmune disorder; the immune system attacks endogenous pancreatic β-cells | Progressive metabolic disorder characterized by insulin resistance | Chronic disorder induced by partial or total pancreatectomy |
Prevalence | 5% to 10% of diagnosed diabetics | 90% to 95% percent of diagnosed diabetics | 1% of diagnosed diabetics |
Onset | Abrupt | Gradual | Shortly after surgery |
Age of onset | Varies (commonly in childhood or puberty) | Commonly over 35 yr | Commonly over 50 yr |
Genetic predisposition | Moderate | Very strong | Moderate |
Body habitus | Thin or normal | Often obese | Normal, overweight or obese |
Ketoacidosis | Common | Rare | Rare |
β-cell depletion | Severe (over 80%) | Mild (24% to 65%) | Mild to total (up to 100%) |
Plasma insulin | Low to absent | Normal or increased | Low to absent |
- Citation: Arutyunyan IV, Fatkhudinov TK, Makarov AV, Elchaninov AV, Sukhikh GT. Regenerative medicine of pancreatic islets. World J Gastroenterol 2020; 26(22): 2948-2966
- URL: https://www.wjgnet.com/1007-9327/full/v26/i22/2948.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i22.2948