Traditional Chinese medicine alleviate gastrointestinal symptoms during bismuth quadruple therapy for Helicobacter pylori infection: A complementary perspective

doi:10.3748/wjg.v32.i9.115555

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Mar 7, 2026 (publication date) through Mar 2, 2026

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World Journal of Gastroenterology

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1007-9327

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 7, 2026; 32(9): 115555
Published online Mar 7, 2026. doi: 10.3748/wjg.v32.i9.115555

Traditional Chinese medicine alleviate gastrointestinal symptoms during bismuth quadruple therapy for Helicobacter pylori infection: A complementary perspective

Yue-Bo Jia, Jing Wang, Li-Kun Guo, Jiang-Hong Ling

Yue-Bo Jia, Jing Wang, Jiang-Hong Ling, Department of Gastroenterology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Li-Kun Guo, Endoscopy Center, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Author contributions: Jia YB wrote the letter; Wang J and Guo LK reviewed literature and added the prospect of probiotics treating Helicobacter pylori-related dyspepsia; Ling JH reviewed the letter, and added the prospect of traditional Chinese medicine for Helicobacter pylori eradication; all authors contributed to the approval of the final version and quality of the letter for publication.

Supported by National TCM Advantageous Specialty Project of National Administration of Traditional Chinese Medicine.

Conflict-of-interest statement: All the authors of this manuscript declare that they have no conflicts of interest.

Corresponding author: Jiang-Hong Ling, PhD, Professor, Department of Gastroenterology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhangheng Road, Shanghai 201203, China. ljh18817424778@163.com

Received: October 20, 2025
Revised: December 9, 2025
Accepted: December 30, 2025
Published online: March 7, 2026
Processing time: 130 Days and 19.7 Hours

Core Tip

Core Tip: The study by Liu et al represents an important step forward in optimizing Helicobacter pylori (H. pylori) eradication therapy. By reducing side effects and improving patient comfort, probiotics offer a practical adjunct to enhance adherence to bismuth quadruple therapy. Traditional Chinese medicine can have similar functions because they have similar advantages in regulating microbiota. We expect in the next few years, more research should be encouraged on the microbiota pathway for eradicating H. pylori infections.