Traditional Chinese medicine alleviate gastrointestinal symptoms during bismuth quadruple therapy for Helicobacter pylori infection: A complementary perspective

Abstract

Liu et al recently published research suggesting that multistrain probiotics significantly relieved bismuth quadruple therapy (BQT)-associated gastrointestinal symptoms without affecting eradication success. They conducted a rigorous randomized, double-blind, placebo-controlled trial, demonstrating that a 4-week regimen of a multistrain probiotic supplement significantly reduced symptoms such as reflux, dyspepsia, and diarrhea. The reduction in side effects and enhanced patient comfort highlight the clinical utility of probiotics as a safe and well-tolerated adjunct to BQT. Our contribution was about to involve the traditional Chinese medicine treating Helicobacter pylori-related chronic gastritis. They can have similar functions in regulating gut microbiota. Future research should build on this foundation to refine probiotic formulations, explore their long-term effects, and clarify their role in achieving higher eradication rates.

Keywords: Helicobacter pylori infection; Traditional Chinese medicine; Gastrointestinal symptoms; Randomized controlled trial; Letter

Core Tip: The study by Liu et al represents an important step forward in optimizing Helicobacter pylori (H. pylori) eradication therapy. By reducing side effects and improving patient comfort, probiotics offer a practical adjunct to enhance adherence to bismuth quadruple therapy. Traditional Chinese medicine can have similar functions because they have similar advantages in regulating microbiota. We expect in the next few years, more research should be encouraged on the microbiota pathway for eradicating H. pylori infections.