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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2026; 32(8): 115077
Published online Feb 28, 2026. doi: 10.3748/wjg.v32.i8.115077
Published online Feb 28, 2026. doi: 10.3748/wjg.v32.i8.115077
Xing-Pi-Qing-Gan decoction alleviates alcoholic liver disease by down-regulating DDIT3 and restoring Nrf2/HO-1 antioxidant signaling: Multi-omics and experimental evidence
Na-Fei Huang, Ping Ling, Xiao-Feng Feng, The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Yu-Jie Xu, Hangzhou School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Yi Zheng, Department of Clinical Nutrition, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
Tao Sun, Department of Hepatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
Co-corresponding authors: Yi Zheng and Tao Sun.
Author contributions: Zheng Y and Sun T contribute equally to this study as co-corresponding authors; Huang NF was responsible for writing - original draft, investigation, formal analysis, conceptualization; Ling P was responsible for software, formal analysis; Xu YJ was responsible for data curation; Feng XF was responsible for validation, supervision; Zheng Y was responsible for methodology, investigation, formal analysis; Sun T was responsible for supervision, resources, project administration, funding acquisition.
Supported by Natural Science Foundation of Zhejiang Province, No. ZCLQN25H2703; Zhejiang TCM Science and Technology Plan, No. 2025ZR126; and the Science and Technology Department of the National Administration of Traditional Chinese Medicine - Administration of Traditional Chinese Medicine of Zhejiang Province Jointly Established Science and Technology Plan Project, No. GZY-ZJ-KJ-24071.
Institutional animal care and use committee statement: All animal procedures were approved by the Institutional Animal Care and Use Committee of Zhejiang University of Chinese Medicine (Approval No. IACUC-202410-15) and were performed in strict accordance with the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals.
Conflict-of-interest statement: The authors declare no competing financial or non-financial interests related to this work.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All raw RNA-sequencing data generated during this study have been submitted to the GEO database, ID GSE310439. Other datasets supporting the conclusions are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tao Sun, MD, Associate Chief Physician, Department of Hepatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, No. 318 Chaowang Road, Gongshu District, Hangzhou 310005, Zhejiang Province, China.
Received: October 15, 2025
Revised: November 24, 2025
Accepted: December 12, 2025
Published online: February 28, 2026
Processing time: 127 Days and 4.9 Hours
Revised: November 24, 2025
Accepted: December 12, 2025
Published online: February 28, 2026
Processing time: 127 Days and 4.9 Hours
Core Tip
Core Tip: Xing-Pi-Qing-Gan decoction (XPQG) is effective in improving ethanol-induced acute liver injury. XPQG alleviates alcoholic liver disease by suppressing DDIT3 and enhancing Nrf2/HO-1-mediated antioxidant responses, reduce lipid accumulation, inflammation, and apoptosis, as validated through multi-omics and experimental studies.