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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2026; 32(3): 114948
Published online Jan 21, 2026. doi: 10.3748/wjg.v32.i3.114948
Published online Jan 21, 2026. doi: 10.3748/wjg.v32.i3.114948
Gamma-glutamyl transferase as a redox-gatekeeper biomarker for pancreatic cystic neoplasms: A concise roadmap from epidemiology to bedside
Ming-Qi Qiu, School of Pharmacy, Inner Mongolia Medical University (Jinshan Campus), Hohhot 010110, Inner Mongolia Autonomous Region, China
Ming-Min Chen, Department of General Practice, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Wen-Jie Yang, Department of Neurosurgery, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China
Wu-Si Qiu, Department of Surgical Education and Research, Department of Neurosurgery, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China
Co-corresponding authors: Ming-Min Chen and Wu-Si Qiu.
Author contributions: Qiu MQ and Qiu WS participated in the formation of the idea; Qiu MQ, Chen MM and Yang WJ performed references acquisition and interpretation; all authors wrote the initial manuscript, and have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wu-Si Qiu, MD, PhD, Associate Chief Physician, Associate Professor, Department of Surgical Education and Research, Department of Neurosurgery, Affiliated Hospital of Hangzhou Normal University, No. 126 Wenzhou Road, Gongshu District, Hangzhou 310015, Zhejiang Province, China. shihai954@163.com
Received: October 9, 2025
Revised: November 13, 2025
Accepted: December 10, 2025
Published online: January 21, 2026
Processing time: 106 Days and 12.4 Hours
Revised: November 13, 2025
Accepted: December 10, 2025
Published online: January 21, 2026
Processing time: 106 Days and 12.4 Hours
Core Tip
Core Tip: This letter embeds the newly discovered gamma-glutamyl transferase-pancreatic cystic neoplasm association within a redox-oncology framework, supplies fresh single-cell evidence for pancreatic GGT1 induction by KRAS, and sketches a pragmatic three-tier roadmap (threshold refinement-multi-omic integration-cost-effectiveness validation) to expedite clinical translation.