Letter to the Editor: Trimetazidine modulates gut microbiota-lipid metabolism axis: A novel avenue for anti-aging interventions

doi:10.3748/wjg.119545

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 21, 2026; 32(27): 119545
Published online Jul 21, 2026. doi: 10.3748/wjg.119545

Letter to the Editor: Trimetazidine modulates gut microbiota-lipid metabolism axis: A novel avenue for anti-aging interventions

Yi Tian, Ting Chen, Hai-Bo Wu

Hai-Bo Wu, Yi Tian, Department of Clinical Medical, Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, Dazhou 635000, Sichuan Province, China

Ting Chen, Department of Clinical Medical, Sichuan University West China Hospital Yingshan Hospital & Yingshan People’s Hospital, Nanchong 637000, Sichuan Province, China

Co-first authors: Hai-Bo Wu and Ting Chen.

Author contributions: Wu HB and Chen T contributed equally to this manuscript and are co-first authors. Wu HB contributed to writing - original draft; Chen T contributed to formal analysis; Tian Y contributed to conceptualization.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Yi Tian, MD, Doctor, Department of Clinical Medical, Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, No. 522 Xiwaita Stone Road, Tongchuan District, Dazhou 635000, Sichuan Province, China. doc.yitian@hotmail.com

Received: January 30, 2026
Revised: February 13, 2026
Accepted: March 10, 2026
Published online: July 21, 2026
Processing time: 158 Days and 12 Hours

Core Tip

Core Tip: In this letter, we discuss a study by Wang et al on the age-related gut microbiome profile and reversal of microbial imbalance using trimetazidine therapy. This study provided compelling evidence that the gut microbiota undergoes significant age-dependent changes, particularly an enrichment of fatty acid oxidation-related microbes in older populations. The authors successfully demonstrated that trimetazidine restored the gut microbial balance and reduced senescence markers in ageing rats, indicating that it exerts potential anti-ageing effects by modulating the microbiota and metabolism.